中国大陆钉螺对氯硝柳胺敏感性的测定  

Sensitivity of Oncomelania Snail to Niclosamide in China

作　　者：戴建荣[1] 周晓农[1] 梁幼生[1] 张燕萍[1] 姜玉骥[1] 奚伟萍[1] 黄轶昕[1] 陈昌[2] 黄铭西[3] 朱荫昌[1] 

机构地区：[1]江苏省血吸虫病防治研究所,无锡214064 [2]中国疾病预防控制中心寄生虫病预防控制所,上海200025 [3]华中科技大学同济医学院,武汉430030

出　　处：《中国寄生虫学与寄生虫病杂志》2002年第2期101-105,共5页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：JRMC资助研究 (No.7 1 4 )~~

摘　　要：目的　了解中国大陆钉螺对氯硝柳胺的敏感性。　方法　运用分层随机抽样方法 ,兼顾我国钉螺孳生地类型 ,抽取了 10省 (市 )、33个县 37个点的钉螺 ,氯硝柳胺用脱氯自来水配成有效浓度为 1.0 0 0 0、 0 .5 0 0 0、0 .2 5 0 0、0 .12 5 0、0 .0 6 2 5、0 .0 313和 0 .0 15 7mg/L的药液 ,在 2 5℃室温下分别进行浸泡杀螺实验。　 结果　 1.0mg/L氯硝柳胺浸泡钉螺 2 4h死亡率达 10 0 % ,各点钉螺的LC50 为 0 .0 32 0～ 0 .16 89mg/L ,均值为 0 .0 92 0mg/L。 0 .5mg/L氯硝柳胺浸泡钉螺 48h死亡率达 10 0 % ,各地区钉螺的LC50 为 0 .0 2 99～ 0 .1114mg/L ,均值为 0 .0 6 2 7mg/L。不同点间钉螺对氯硝柳胺敏感性差异有显著性意义 (P <0 .0 1)。　结论　不同点间钉螺对氯硝柳胺敏感性存在差异 ,但 1.0mg/L氯硝柳胺可有效浸杀我国所有地区的钉螺。Objective To understand the variation in response of Oncomelania hupensis to niclosamide. Methods Snails were collected from 37 sampling areas distributed in 10 provinces (municipalities) using random environmental sampling methods in accordance with the different types and categories of snail habitats. In laboratory the snails were immersed in solutions of niclosamide for 24 and 48 hours at 25℃. Results 1.0 mg/L niclosamide showed 100% killing effect on snails in 24 hours. The LC 50 concentrations for snails immersed for 24 hours ranged from 0.0320 to 0.1689 mg/L with a mean value of 0.0920 mg/L. 0.5 mg/L niclosamide showed 100% killing effect on snails in 48 hours. The LC 50 values for snails immersed for 48 hours ranged between 0.0299 and 0.1114 mg/L with a mean of 0.0627 mg/L. There is a significant difference in snail sensitivity to niclosamide between sampling areas. Conclusion The sensitivity to niclosamide varied in snails from different sampling fields, but the chemical in a concentration of 1.0 mg/L showed 100% effect of killing snails, which is consistent to the manual of schistosomiasis control.

关 键 词：湖北钉螺 氯硝柳胺 敏感性 测定 

分 类 号：R979.8[医药卫生—药品]