绝经妇女血清睾酮和前臂骨密度之间的相关性  

Study on the Realationship Between Serum Testosterone Level and Forearm Distal Bone Density in Post-menopausal Women

作　　者：李文琦[1] 周争立[1] 李欣[1] 周激文[1] 

机构地区：[1]云南省计划生育技术科学研究所,650021

出　　处：《放射免疫学杂志》2002年第2期82-84,共3页Journal of Radioimmanology

摘　　要：目的 :为了研究绝经后妇女的雄激素水平与骨密度之间的关系。方法 :测定了 39例从未服用过雌激素和钙剂 ,其血清雌激素水平基本相同 ,但骨密度水平有一定差异的绝经后妇女的血清睾酮水平 ,并将这些妇女依骨密度水平分为正常和骨质疏松两个组。结果 :经过统计学分析 ,发现两组血清睾酮水平有非常显著的差异 (p <0 0 0 1)。经过直线回归计算和相关分析 ,发现两个组的睾酮和各自匹配的骨密度水平呈平行变化 ,线性关系良好 ,相关系数分别为 0 72及 0 75。经相关检验 ,两个p <0 0 0 1,有高度相关。将两r值进一步进行显著性检验 ,U值为 0 14,说明两组的正相关关系无显著性差异 (p>0 0 5 )。结论 :血清睾酮水平低与骨密度与骨质疏松密切相关。Objective To study the relationship between the androgen level and bone density in post-menopausal women. Methods Serum tostosterone (T) level and forearm distal bone density (BMD) were measured in 39 past-menopausal women who had never taken any estrogen or calcium preparations. Their serum estradiol (E_2) levels were about the same. According to their BMD, the 39 subjects were divided into normal (n=32) and osteoporotic (n=17) groups. Results The mean serum testosterone (T) level in the normal group was significantly higher than that in the osteoporotic group ( p <0 001). Changes in T level were parallel to those of BMD. There was markedly positive cor-relationship between the T level and BMD in both group ( r__1=0.72, r__2=0.75; p<0 001 ). The U for r__1 and r__2 was 0 14, suggesting similarity of the positive cor-relatisnship for both groups ( p >0 05). Conclusion Serum testosterone level seems to bear close relationship with bone density and osteoporosis.

关 键 词：相关性 绝经后妇女 骨密度 骨质疏松 睾酮 

分 类 号：R681[医药卫生—骨科学]