经皮甲状腺体内乙醇注射治疗Graves病的临床研究  

Clinical Results of Treating Graves's Disease with Percutanuous Intrathyoidal Ethanol Injection

作　　者：姜国良[1] 李向东[2] 钱震东 汪诚 江中林 张登宝 程强[1] 叶献词 吴德忠 陈莹枝 祝淑芳 陈勇 

机构地区：[1]安徽省铜陵有色职工总医院内三科,244000 [2]安徽省铜陵有色职工总医院普外科 [3]安徽省铜陵有色职工总医院放免中心

出　　处：《放射免疫学杂志》2002年第2期87-89,共3页Journal of Radioimmanology

摘　　要：目的 :观察经皮甲状腺体内乙醇注射对原发性甲亢的疗效。方法 :选择 42例确诊为Graves病(GD)的患者行经皮乙醇注射 (PEI)治疗 ,观察临床疗效、甲状腺激素水平 (TT3 、TT4 、FT3 、FT4 、TSH)及甲状腺大小的变化 ,随访半年。同时选择 47例口服抗甲状腺药物 (PATD)的患者进行对照 ,将其结果进行统计学处理及临床分析。结果 :PEI治疗 42例病人 ,其中治愈 17例 ,好转 2 4例 ,无效 1例 ,总有效率为 97 6 % ,与对照组疗效相比 ,差别无显著性 (p >0 0 5 ) ;在改善甲状腺大小方面 ,PEI组疗效明显优于对照组 ,差别有显著性 (p <0 0 1)。而且 ,PEI治疗GD未发现严重副反应。结论 :PEI治疗GD简单、实用、经济、有效 ,为GD的治疗提供了一条新的途径。Objective To observe the effectiveness of percutanuous intrathyoidal ethanol injection in the treatment of Graves's disease. Methods 42 patients with Graves' disease were given percutaneous intrathyroidal ethanol injection (PEI) for treatment. The control group consistes of 47 patients given per-oral antithyroid drug (PATD). Clinical responce, levels of serum TT_3, TT_4, FT_3, FT_4, TSH and size of thyroid were observed and followed up for six months. Results In PEI group, 17 cases were cured, 24 cases were improved and only one case had no responce. Total effective rate was 97.6% with no significant difference from that of PATD ( p >0.05). The size of gland after treatment were significantly smaller in PEI than that of PATD ( p <0.01). No severe adverse effect occurred in the PEI group. Conclusion PEI is a new way in treating GD which is simple economical and effective.

关 键 词：经皮甲状腺体内乙醇注射 临床研究 乙醇 治疗 GRAVES病 

分 类 号：R581.105[医药卫生—内分泌]