北京地区中老年人糖尿病和IGT患病率与增龄相关性的分析  

Prevalent changes of diabetes and IGT with age increment in middle and old age population in Beijing

作　　者：杨泽[1] 郑宏[1] 高芳坤[4] 佟之复[1] 于普林[1] 唐雷[1] 史晓红[4] 范钦颖[2] 王秉治 张培兰[1] 曾平[1] 

机构地区：[1]卫生部北京医院,卫生部老年医学研究所,邮政编码100730 [2]卫生部中日友好医院保健科 [3]北京市顺义县人民医院医务科 [4]不详

出　　处：《中国糖尿病杂志》2002年第2期69-73,共5页Chinese Journal of Diabetes

基　　金："九五"攻关课题 (96- 90 6- 0 5- 0 1 )

摘　　要：目的　阐明中老年人糖尿病 (DM)和 IGT患病的增龄性特点及增龄的患病风险。方法　采用随机分级整群抽样方法 ,横断面调查北京市城乡 4个社区 2 35 4例≥ 4 0岁的中老年人。结果　 DM患病率为 11.36 % (标化率 :10 .6 4 % ) ,IGT患病率为 12 .17% (标化率 :11.5 6 % ) ,其与增龄有显著的相关性 (DM:r =0 .99,P =0 .0 0 2 ;IGT:r =0 .92 ,P =0 .0 2 9)。不同年龄组的血糖均值秩和分析 (IGT:χ2 =9.816 ,P =0 .0 4 4 ,总体 :χ2 =10 6 .94 4 ,P <0 .0 0 0 5 )在IGT和总体中证明有显著随年龄增加而增长的趋势。有 3个显著不同的患病风险 (OR)年龄阶段 ,即 4 0～ 4 9岁最低(DM:4 .95 % ,OR=0 .4 1;IGT:8.35 % ,OR=0 .6 6 ) ;5 0～ 6 9岁较高 (DM:12 .13%～ 13.5 7% ,OR=1.0 8～ 1.2 2 ;IGT:11.0 2 %～ 13.6 0 % ,OR=0 .89～ 1.13) ;70～ 99岁最高 (DM:19.0 2 %～ 2 1.0 5 % ,OR=1.83～ 2 .0 8;IGT:19.0 1%～2 1.0 5 % ,OR=1.6 9～ 1.92 )。患病高峰年龄为 DM(95 %可信区间 ,CI) :4 1.0～ 80 .4岁 ,IGT(95 % CI) :36 .9～ 82 .1岁。结论　因 DM和 IGT患者人数随增龄积累 ,年龄越大 ,患病率越高 ,表现出高龄群体高患病风险的增龄特点。年龄是 DM发生的一独立危险因素。Objective To show prevalent features and odds ratio as well as attributive risks of diabetes mellitus and impaired glucose tolerance with age increment in the middle and old age population.Methods We used cross over section epidemiology survey throughout random stratified population sampling, comparing prevalent characteristics of diabetes and IGT in the 2354 population aged more than 40 in 4 communities in Beijing in 1997.Results The diabetes prevalence rising with aging of population has been showed by correlation of diabetes prevalence to middle and old aged populations (DM:r=0 99,P=0 002; IGT:r=0 92,P=0 029). By rank sum test, the mean blood glucose levels in the population and the patients with IGT varied significantly among age groups (IGT: χ 2=9 816, P=0 044,total:χ 2=106 944,P<0 0005). Both prevalence and odds ratio of diabetes or IGT in the population were increased with age increment. There appeared 3 different age stages with distinct prevalence and odds ratio of diabetes and IGT: 40 years old group(DM:4 95%,OR=0 41;IGT:8 35%,OR=0 66);50～69 years old(DM:12 13～13 57%,OR=1 08～1 22;IGT:11 02～13 60%,OR=0 89～1 13);and 70～99 years old(DM:19 02～21 05%,OR=1 83～2 08;IGT:19 01～21 05 %,OR=1 69～1 92). All results support the prevalence and odds ratio increasing with age rising in middle and old aged population.Conclusion Patients with diabetes and IGT are accumulating with age increment in the middle and old aged population. It showed that age increment is an independent risk factor for diabetes and IGT in middle and old age population.

关 键 词：北京地区 患病率 中老年人 糖尿病 糖耐量低减 增龄性 

分 类 号：R587.1[医药卫生—内分泌]