盐酸精氨酸与醋酸精氨酸对机体酸碱平衡影响的实验研究  

Effects of Arginine Hydrochloride and Arginine Acetate on Body Acid-base Equilibrium

作　　者：彭曦[1] 尤忠义[1] 王裴[1] 汪仕良[1] 

机构地区：[1]第三军医大学附属西南医院烧伤研究所,重庆市400038

出　　处：《中国药房》2002年第4期201-202,共2页China Pharmacy

基　　金：军队科技进步一等奖科研项目 (96-1-8-1);国家科技进步二等奖(15-2-008-01)科研项目的部分内容

摘　　要：目的 :观察盐酸精氨酸与醋酸精氨酸对严重创伤后机体酸碱平衡的影响。方法 :采用30 %Ⅲ°烧伤家兔及正常大鼠灌喂模型 ,随机分为盐酸组和醋酸组 ,分别灌喂盐酸精氨酸和醋酸精氨酸 ,剂量为2 4g/(kg·d) ,连续7d。观察两种药物对烧伤大白兔及正常大鼠酸碱平衡和氯离子代谢的影响。结果 :两组正常大鼠连续用药7d后 ,反映酸碱平衡的各项指标及血浆氯离子水平无明显改变(P>0 05) ;烧伤家兔用药7d后盐酸组出现代谢性酸中毒 ,血浆氯离子含量也明显增高 ,而醋酸组变化不明显。结论 :严重烧伤家兔长时间大剂量应用盐酸精氨酸可导致高氯性酸中毒 ,应用醋酸精氨酸未造成明显不良反应 ,两种药物对正常大鼠均未产生不利影响。OBJECTIVE:To study the effects of arginine hydrochloride and arginine acetate on body acid-base equilibrium after severe trauma.METHODS:The rabbits inflicted with 30% total body surface area full thickness flame burn and normal rats were fed arginine hydrochloride or arginine acetate 2.4g(kg·d) for 7 days respectively,namely hydrochloride group and acetate group.The influence of two kinds of arginine on acid-base equilibrium and plasma chlorine ion were observed in burned rabbits and normal rat.RESULTS:No effects of both arginine hydrochloride and arginine acetate on acid-base equilibrium and chlorine ion metabolism were found in normal rats(P>0.05).However,metabolic acidosis and hyperchloremia were observed with feeding arginine hydrochloride for 7 days in severe burned rabbits,and no such significant changes were found in arginine acetate group.CONCLUSION:Arginine acetate is safer than arginine hydrochloride in severe burned rabbits.

关 键 词：盐酸精氨酸 醋酸精氨酸 酸碱平衡 家兔 大鼠 药理 

分 类 号：R977.4[医药卫生—药品]