卡托普利亲水凝胶缓释片的制备及体外释放影响因素  

Preparation of Captopril Hydrophilic Gel Sustained-release Tablet and Influencing Factors on Its Release in Vitro

作　　者：高迎春[1] 文爱东[1] 蒋永培[1] 赵磊[1] 

机构地区：[1]第四军医大学西京医院药剂科,西安市710032

出　　处：《中国药房》2002年第4期211-213,共3页China Pharmacy

摘　　要：目的 :制备卡托普利亲水凝胶缓释片 ,并考察其体外释放影响因素。方法 :以羟丙基甲基纤维素为骨架材料 ,粉末直接压片制备卡托普利缓释片。以释放度为指标 ,评价多种因素对释放度的影响。结果与结论 :制得片剂体外释药行为符合Higuchi方程 ;羟丙基甲基纤维素用量达15 %即有缓释效果 ,用量为60 %时缓释效果最佳 ;MethocelK系列比60RT、75RT系列释放慢 ;填充剂以乳糖为佳 ,提高填充剂用量可明显减慢卡托普利的释放 ;浆法较转篮法释放略快 ;压片力和释放介质 pH值对溶出无明显影响。OBJECTIVE:To prepare captopril hydrophilic gel sustained-release tablet and study the influencing factors on its release METHODS:With HPMC as the matrix,the tablets were prepared by direct compression method and influencing factors on release were studied RESULTS & CONCLUSION:The in vitro release of prepared tablets conformed to Higuchi equation The HPMC matrix tablet could release in a sustained way when the proportion of HPMC was at least 15% in weight and the best proportion was 60%;The dissolution of Methocel K was slower than 60RT or 75RT;Taking lactose as the filler was better than starch or CaSO4;When the proportion of lactose increased,the dissolution sharply decreased;The tablet dissolved more rapidly with paddle method than with rotating basket methos,compression force and pH of dissolution medium affected the release very little

关 键 词：制备 影响因素 卡托普利 羟丙基甲基纤维素 骨架片 释放度 

分 类 号：R972.4[医药卫生—药品]