肾移植受者环孢素A治疗窗浓度研究  

Study on CsA Therapeutic Window Concentration in Renal Transplant Recipients

作　　者：万江华[1] 靳风烁[1] 李黔生[1] 江军[1] 李彦锋[1] 姜庆[1] 徐序广[1] 张勇[1] 朱方强[1] 

机构地区：[1]第三军医大学大坪医院泌尿外科,重庆市400042

出　　处：《中国药房》2002年第4期224-225,共2页China Pharmacy

摘　　要：目的 :寻找环孢素A(CsA )在肾移植受者三联免疫抑制用药方案中的理想治疗窗浓度。方法 :用特异性荧光偏振免疫法测定268例患者全血CsA谷值浓度 ,并按术后时间及临床诊断分组比较。结果 :CsA理想治疗窗浓度为 :术后1mo内300～400μg/L ,2mo～3mo内250～350μg/L ,4mo～6mo内150～250μg/L ,7mo～12mo内100～200μg/L ,12mo以后100～150μg/L。结论 :CsA在理想治疗窗浓度内 ,既能达到满意的免疫抑制效果 。OBJECTIVE:To establish an optimal therapeutic window concentration of CsA trough levels in renal transplant recipients on triple immunosuppressants regimen METHODS:A total 1 874 samples from 268 renal transplant recipients were measured by fluorescence polarization immunoassay(FPIA) According to the duration after operation and clinical diagnoses ,the whole blood CsA trough levels were compared among subgroups RESULTS:The optimal therapeutic window concentration of CsA was 300～400μg/L(within 1 month after operation),250～350μg/L(2nd～3rd month),150～250μg/L(4th～6th month),100～200μg/L(7th～12th month)and 100～150μg/L(more than 12 months) CONCLUSION:The above mentioned therapeutic window concentratin of CsA trough levels was ideal for renal transplant recipients with no marked acute toxic effects and rejection reaction

关 键 词：环孢素A 肾移植 血药浓度监测 特异性荧光偏振免疫法 

分 类 号：R699.2[医药卫生—泌尿科学] R978.11[医药卫生—外科学]