SP-B、SP-C对肺表面活性物质功能的影响  

Effect of SP-B and SP-C on Function of Pulmonary Surfactant

作　　者：薄玉龙[1] 徐咏梅[1] 王海宽[2] 段东洋 张瑞芹[1] 李文志[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院麻醉科,黑龙江哈尔滨150086 [2]齐齐哈尔医学院第一附属医院麻醉科,黑龙江齐齐哈尔161041 [3]铁力市医院麻醉科,黑龙江铁力152500

出　　处：《黑龙江医学》2002年第5期343-344,共2页Heilongjiang Medical Journal

摘　　要：目的　探讨肺表面活性物质相关蛋白B、C(SP -B、SP -C)对肺表面活性物质功能影响。方法　将不含有SP -A、SP -D的肺表面活性物质脂质部分和脂质部分加入SP -B和 (或 )SP -C配制成实验液体。用气泡型表面张力计测定最小表面张力 (γmin)。向未成熟胎兔气道内注入实验液体后进行人工通气 ,测定潮气量。结果　脂质部分加入SP -B和SP -C后γmin明显下降至 (2 .1± 0 .8)mN/m ,并明显增加动物的潮气量至2 5 .3ml/kg± 3.9ml/kg。结论　SP -B、SP -C协同可增加肺表面活性物质的功能。Objective To investigate the effects of surfactant-associated proteins (SP-B and SP-C) on the function of pulmonary surfactant. Methods The swine surfactants without content of SP-A and SP-D and lipid fraction (LF) were isolated. In addition, several reconstituted surfactants were prepared by adding SP-B and/or SP-C into LF. The minimum surface tension (γ min ) of these samples was recorded by pulsating bubble technique. Surfactant-deficient immature rabbits were instilled by these samples through the trachea and their tidal volumes were measured. Results The γ min of LF with SP-B and SP-C decreased significantly to 2.1±0.8mN/m, and the tidal volumes of animals increased to 25.3±3.9ml/kg. Conclusion: Both SP-B and SP-C were necessary to enhance the function of surfactant.

关 键 词：SP-B SP-C 肺表面活性物质 影响 动物实验 

分 类 号：R332.2[医药卫生—人体生理学]