全小肠切除大鼠模型的建立  

Rats Model of Total Small Bowel Resection

作　　者：张焱焱[1] 吴文川[2] 靳大勇[2] 

机构地区：[1]华北煤炭医学院附属医院 [2]上海医科大学中山医院

出　　处：《中国临床营养杂志》2002年第1期24-26,共3页Chinese Journal of Clinical Nutrition

摘　　要：目的建立全小肠切除大鼠模型。方法保留距Treitz韧带及距回盲部1cm的小肠,切除中间段全部小肠,行空-回肠端端吻合术。术后行肠内营养(EN)10天。结果40只大鼠中术后生存率1周为100%,4周为58%,8周为30%,12周为25%,与预实验组相比有明显差异(P<0.001)。结论该全小肠切除大鼠模型创建方法切实可行。Objective To establish a rat model of total small bowel resection.Methods Total small bowel resection performed approximately1cm distal to the ligament of Treitz and1cm proximal to the ileocecal junction.Intestinal continuity was restored by jejuno-ileum end-to-end,single-layered,anas-tomosis using interrupted7-0monofilament sutures.Dur ing the post operative ten-days,the rats re cei-ved the Pepti-200080ml /d.After then all rats were treated with solid nutrition NIH-7620g/d.Results At 1,4,8,and12weeks after operation,the rat survival rates were100%,58%,30%,and25%respectively.Conclusions The method of establishing rat model of total small bowel resec-tion is feasible.

关 键 词：全小肠切除 动物模型 空-回肠端端吻合术 肠内营养 

分 类 号：R656.7[医药卫生—外科学]