短杆菌肽在十八烷基硫醇自组装单层膜上的通道行为  

The Channel Behavior of Gramicidin in Mercaptan Self-assembled Monolayer Membrane

作　　者：郭继东[1] 邢巍[1] 陆天虹[1] 杨辉[2] 

机构地区：[1]中国科学院长春应用化学研究所,长春130022 [2]南京师范大学化学系,南京210097

出　　处：《高等学校化学学报》2002年第5期958-960,共3页Chemical Journal of Chinese Universities

基　　金：江苏省教育委员会和厦门大学固体表面物理化学国家重点实验室资助.

摘　　要：短杆菌肽是短杆芽孢菌在芽孢形成过程中合成的一组憎水十五肽, 它能在脂双层膜上形成一价阳离子通道, 允许一些一价阳离子通过. 短杆菌肽离子通道研究在天然双层膜以及人工双层膜, 如类脂双层膜(BLM)、脂质体上开展的较多, 而基于支撑膜的研究则极少[1～4]. 本文在金电极上制备硫醇自组装单层膜, 研究了短杆菌肽的离子通道行为, 并提出了可能的机理.Abstract The present paper reports the channel behavior of gramicidin in mercaptan self-assembled mono-layer on the surface of the gold electrode by using the electrochemical method. The current responses to K+ ions and the electrode potential for the gold electrodes modified .with self-assembled mercaptan mono-layer incorporating and not incorporating gramicidin D were compared. The results firstly indicated that gramicidin D molecules can be incorporated into the mercaptan monolayer assembled on the surface of the gold electrode and form monovalent ion channel. A mechanism of the phenomenon was proposed.

关 键 词：短杆菌肽 十八烷基硫醇 自组装单分子层膜 离子通道 

分 类 号：Q516[生物学—生物化学]