三七皂甙对大鼠脑缺血再灌注损伤的保护作用  

Study on protective effect of Panax notoginseng saponins on brain ischemic reperfusion damage in rats

作　　者：王根发[1] 王文安[1] 周永炜[1] 陈伟[1] 姚革[1] 朱弘[1] 

机构地区：[1]上海第二医科大学附属新华医院,上海200092

出　　处：《中国临床康复》2002年第9期1268-1269,W001,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的探讨三七皂甙对大鼠脑缺血再灌注后的保护作用。方法采用线栓法建立鼠大脑中动脉局灶缺血再灌注模型。于缺血2h再灌注22h,测定脑梗死体积并观察血脑屏障破坏的程度。结果再灌注后22h,三七皂甙治疗组可有效降低脑梗死体积,明显减轻脑缺血区血脑屏障破坏的程度。结论三七皂甙对脑缺血再灌注有确切的脑保护作用,并能减轻脑缺血再灌注对血脑屏障破坏的程度。Objective To evaluate the protective effects o f Panax notoginseng saponins on cere bral ischemia -reperfusion damage i n rats.Method Using intravascular thread model wi th two hours of occlusion and 22hours of reperfusion in rats,brain infarc tion size and the degree of blood brain barrier(BBB)disruption in ischemic region were e valuated.Result The brain infarction volume and area of BBB disruption were dramatically decreased in treatment group as compared with control group.Conclusion Panax notoginseng saponin has defin ite pro-tective effect on cerebral ischemia-reperfusion injury.It can also attenuate BBB disruption.

关 键 词：保护作用 脑缺血 再灌注损伤 三七皂甙 血脑屏障 

分 类 号：R277.733[医药卫生—中医学] R285