弥可保肌肉注射改善糖尿病性周围神经传导速度的定量测试  

Clinical trial on effects of methylc obalamin in the treatment of diabetic neuropathy

作　　者：陈日坚[1] 郑颖嘉[1] 徐丽珊[1] 

机构地区：[1]汕头市中心医院,广东汕头515031

出　　处：《中国临床康复》2002年第9期1280-1281,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的了解弥可保肌肉注射治疗糖尿病性周围神经病变的疗效和对周围神经传导速度的改善情况。方法有自觉症状并双膝反射消失的确诊糖尿病病人30例,肌注弥可保500μg/d,持续4周。治疗前后检测左侧下肢腓总神经的感觉和运动传导速度,对结果进行t检验统计学分析。结果经过4周的治疗后,30例病人的左侧下肢腓总神经的感觉和运动传导速度均较治疗前有明显加快(P<0.05)。自觉症状消失的为20%;明显减轻的为40%;减轻的为33.3%,膝反射出现的有60%。未发现副作用。结论弥可保肌肉注射能改善周围神经传导速度;对糖尿病性周围神经病变有良好的治疗效果,未发现副作用。Objective To investigate the effect of mecobalamin on diabetic neuropathy by intra muscular.Methods 30patients with diabetic mellitus,who had got neuropathic symptoms and discharge in knee jerk,were treated with mecobalamin 500μg intramuscularly one time per day for four weeks.The motor and sensory nerve conduction velocity of the left peronaeus communis nerve was observed before and after the treatment.Results Four weeks after the treatment,sign ificant increase in the motor and sen sory nerve conduction velocity of th e left peronaeus communis nerve were observed in the 30patients(P<0.05).The symptoms disappeared in 20%patients,obviously improved in40%and improved in 33.3%.60%patien ts got their knee jerk back.No obviou s side effects were found.Conclusions Mecobalamin can increase the nerve conduction veloc ity by intramuscular and be effectiv e to diabetic neuropathy with no side effect.

关 键 词：肌肉注射 糖尿病性周围神经病变 疗效 周围神经传导速度 弥可保 糖尿病 神经病变 

分 类 号：R587.2[医药卫生—内分泌] R745[医药卫生—内科学]