N-氯化三甲氨基乙酰氯的合成研究  

Study on Synthesis of N-Chlorobetainyl Chloride

作　　者：张书文[1] 李江芝[2] 

机构地区：[1]北华大学师范理学院，吉林吉林132013 [2]吉林市毓文中学，吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2002年第2期110-112,共3页Journal of Beihua University（Natural Science）

摘　　要：研究了以盐酸甜菜碱为原料,以亚硫酰氯为氯化剂合成N-氯化三甲氨基乙酰氯的方法.考察了反应中的物料配比、反应温度、反应时间以及产物处理等因素对产率的影响.结果表明,最佳反应条件为:盐酸甜菜碱与亚硫酰氯的量比为n(C5H12ClNO2):n(SOCl2)=1:1.3～1:1.4,反应温度为68～70℃,反应时间为1.5～2 h.在此条件下反应的产率和产品的纯度均可达到99%以上.The synthesis method of N-Chlorobetainyl chloride with betaine hydrochloride as raw material and with thionyl chloride as chloridate agent were studied.The effect of ratio of the raw materials,temperature of the reaction,time of the reaction and product treatment on yield were studied.The results showed that the optimal reaction condition were as follows:the mole ratio of betaine hydrochloride and thionyl chloride 1∶1.3～1∶1.4,the reaction temperature 68～70℃ and the reaction time 1.5～2?h.The yield and purity of product was over 99%.

关 键 词：N-氯化三甲氨基乙酰氯 N-氯化甜菜碱酰氯 盐酸甜菜碱 亚硫酰氯 合成 物料配比 反应温度 

分 类 号：O623.732[理学—有机化学]