α-氰基丙烯酸酯医用胶在几丁质室修复兔颞骨内面神经缺损中的应用  

APPLICATION OF α-CYANOACRYLATE MEDICAL ADHESIVE IN FIXATION OF INTRATEMPORAL FACIAL NERVE WITHIN CHITIN CHAMBER

作　　者：蔡萍[1] 刘公汉[1] 华清泉[1] 吴展元[1] 肖伯奎[1] 

机构地区：[1]武汉大学人民医院耳鼻咽-头颈外科,武汉430060

出　　处：《中国修复重建外科杂志》2002年第3期158-160,共3页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：湖北省教育委员会青年基金资助项目 (96B0 6)

摘　　要：目的　探讨α-氰基丙烯酸酯医用胶应用于几丁质室修复颞骨内面神经缺损神经固定的可行性及神经再生的效果。方法　成年大耳白兔 4 8只 ,左耳颞骨内面神经缺损均用几丁质室桥接 ,固定颞骨内面神经的方法为实验组采用α-氰基丙烯酸酯医用胶粘合法 ,对照组采用缝合法及自然放置法。术后 1、3个月进行功能测试和组织形态学研究。结果　医用胶粘合作用强 ,能将颞骨内面神经固定于几丁质室内而不引起几丁质室变形、豁裂 ;粘合法神经再生成功率高 ,再生神经纤维排列整齐、密集 ,功能恢复良好 ,优于缝合法和自然放置法。结论　几丁质室修复兔颞骨内面神经缺损应用α-氰基丙烯酸酯医用胶固定颞骨内面神经切实可行 ,方法简便、省时 。Objective To study the feasibility of α cyanoacrylate medical adhesive in fixation of intratemporal facial nerve when nerve was repaired within chitin chamber, and to investigate the nerve regeneration. Methods Nerve defect of 6 mm was made in left intratemporal facial nerves of 48 rabbits. All the defects were bridged with chitin chamber and were fixed by α cyanoacrylate medical adhesive, surgical suture and natural union. Nerve function test and histomorphological examination were carried out at 1 month and 3 months after repair. Results It was observed that the nerve was fixed firmly to the chamber with no crack or crease by α cyanoacrylate medical adhesive. The regenerated new nerve fibers were more regular and denser and the neurological function recovered much better in the group fixed by α cyanoacrylate medical adhesive than in the groups those fixed by surgical suture and natural union. Conclusion The medical adhesive is strong in adhesion and beneficial to nerve repair; repair of intratemporal facial nerve defect within chitin chamber fixed by α cyanoacrylate medical adhesive is feasible, simple and timesaving.

关 键 词：颞骨内面神经损伤 几丁质室 α-氰基丙烯酸酯医用胶 神经修复 神经再生 

分 类 号：R616[医药卫生—外科学]