化学致敏作用剂量反应关系的研究  

Experimental Study on Dose-response Relationship of Chemical Sensitization

作　　者：黄俊[1] 王翔朴[1] 陈本美[1] 周晓娟[1] 黄安辉[1] 陶炼晖 

机构地区：[1]湖南医科大学环境医学研究室,长沙410078

出　　处：《卫生毒理学杂志》1991年第1期10-13,共4页Journal of Health Toxicology

基　　金：国家自然科学基金

摘　　要：致敏实验表明,TDI速发型过敏效应和DNCB迟发型过敏效应,均明显受其致敏剂量和激发剂量的影响,剂量越大,过敏反应越强。因此,化学物的过敏反应与其一般毒作用一样显示出明显的剂量-反应关系。This study investigated the relationship of exposure concentrations of toluene diisocyanate(TDI) and blood histamine contents and mast cell degranulation indices ( MCDI ) which were generally accepted as sensitive probes to immediate hypersensitivity of chemicals.The study also explored the dose-response relationship of delayed onset hypersensitivity of DNCB by mice ear swelling test. The results showed that there was a dose-response relationship in both immediate and delayed onset hypersensitivity of chemicals. It is prospective and important to establish safety levels of chemicals for reduction of allergic impairments from them.

关 键 词：化学致敏作用 剂量反应关系 

分 类 号：R114[医药卫生—卫生毒理学]