橡胶工人淋巴细胞DNA链断裂的研究  

Studies on breakage in DNA chain of lymphocytes in rubber workers

作　　者：陈月华[1] 朱昌淇[1] 韦拔雄[1] 江朝强[1] 林大庆[2] 许启荣[1] 

机构地区：[1]广州市第十二人民医院,广东广州510620 [2]香港大学社会医学系

出　　处：《中国工业医学杂志》2002年第1期10-12,共3页Chinese Journal of Industrial Medicine

基　　金：广东省科技厅资助;广州市卫生局资助 (编号 :98- 1 31 )

摘　　要：目的　观察橡胶生产的职业暴露对作业工人淋巴细胞DNA损伤的影响。方法　应用彗星试验检测某橡胶厂 2 81名生产工人淋巴细胞DNA的损伤 ,以 90名管理人员为对照组。结果　生产工人的彗星矩 (TM )大于管理人员(1 77μm与 1 5 2 μm ,P =0 0 4) ,6个工种中以混合车间工人的TM值最大 ,其余依次为整理、压延、硫化和维修等组 ,管理人员组的TM值最小 (F =3 2 1,P =0 0 0 8)。吸烟 (P =0 0 12 )、饮酒 (P =0 0 13 )可使TM值显著增加。结论　橡胶生产的职业接触、吸烟可致淋巴细胞DNA损伤。Objective To study the effects of exposure to rubber production on lymphocytic DNA damage in the workers.Methods With comet assay,lymphocytic damage in 281 production workers and 90 managerial workers of a rubber factory were examined for lymphocytic DNA damage.Results Tail moment(TM)in comet assay was greater in the production workers(1 77μm)than in the managerial workers(1 52μm),with a P value of 0 04,and the largest TM was observed in workers of the mixers,followed by the finishers,the calendering workers,vulcanizers and maintenance workers,and the smallest TM was seen in the managerial workers,with F of 3 21 and P value of 0 008.TM could be increased by smoking,adjusted for other covariates.Conclusions Occupational exposure in rubber production and smoking could cause lymphocytic DNA damage in the workers.

关 键 词：职业接触 慧星试验 DNA损伤 作业工人 

分 类 号：R135.1[医药卫生—劳动卫生]