苯乙烯对接触男工的遗传毒性  

Genotoxicity of exposure to styrene in male workers

作　　者：陈锦[1] 沈波 程怀民 程生英 李跃平[1] 林炜[1] 李胜阳[1] 

机构地区：[1]福建医科大学预防医学系,福建福州350004 [2]福州市晋安区防疫站,福建福州350000

出　　处：《中国工业医学杂志》2002年第1期13-14,18,共3页Chinese Journal of Industrial Medicine

基　　金：福建省卫生厅青年基金资助 (编号 :99- 1 - 2 0 )

摘　　要：目的　探讨苯乙烯对作业工人的遗传损害。方法　选择某厂从事苯乙烯作业男工 3 0名 ,平均工龄 4 5年 ,以微核检测进行细胞遗传毒性效应研究。结果　工人在苯乙烯平均浓度为 99mg/m3的作业环境中工作 ,微核发生率明显增高 ,且随着工龄的延长 ,微核发生率有增高的趋势。结论　苯乙烯对接触男工有一定的遗传毒作用 ,应引起重视 ,并加强对苯乙烯作业环境的监测和作业人群的防护。Objective To explore the genetic damage to male workers exposed to styrene.Methods Thirty male workers exposed to styrene and 44 unexposed controls,with an average length of employment of 4 5 years,were selected from a factory,and 0 3 ml of blood were collected from each of them and cultured for 72 hours for examination of lymphocytic micronucleus as a genotoxic measure.Results Micronucleus rate in those working in an environment with 99 mg/m 3 of styrene increased significantly in comparison with unexposed controls,and increased with length of employment.Conclusions Styrene could cause genotoxicity in exposed workers,and environmental monitoring and protecting for the exposed workers should be strengthened.

关 键 词：苯乙烯 遗传毒性 淋巴细胞微核 作业工人 男工 

分 类 号：R994.3[医药卫生—毒理学]