铅致幼鼠海马回及附近皮质细胞凋亡的实验研究  

The experimental study on apoptosis of hippocampus and cortex cells in rat offsprings exposed to lead

作　　者：逯晓波[1] 吕相征[1] 郑丽舒[1] 李北利[1] 刘秋芳[1] 蔡原[1] 

机构地区：[1]中国医科大学公共卫生学院卫生毒理教研室,辽宁沈阳110001

出　　处：《中国工业医学杂志》2002年第1期19-21,共3页Chinese Journal of Industrial Medicine

摘　　要：目的　从细胞凋亡的角度探讨铅的发育神经毒性。方法　大鼠孕期及哺乳期不同剂量染铅 ,用原子吸收分光光度法测定仔鼠血、脑铅含量 ,取海马回及附近皮质用TUNEL法测定凋亡细胞数量。结果　染铅使出生后 7天幼鼠海马回及附近皮质的细胞凋亡数量增加 ,但对出生后 2 1天幼鼠的影响不明显。结论　铅可通过增加海马回及附近皮质细胞凋亡数量而表现出发育神经毒性。Objective To study the developmental neurotoxicity.Method The offsprings of rats exposed to lead during pregnant and breast feeding period were used to determine the lead content in blood and brain,the apoptotic cells in hippocampus and cortex were also assayed by TUNEL method.Result The number of apoptotic cells in hippocampus and nearby cortex increased in the young rats at the 7th day after birth,but no obvious change in those at the 21st day after birth.Conclusion Lead could induce developmental neurotoxicity by excessive apoptosis of hippocampus and nearby cortex cells during developmental period.

关 键 词：实验研究 铅 海马 细胞凋亡 发育神经毒性 毒理学 

分 类 号：R995[医药卫生—毒理学] R992[医药卫生—药学]