阿托品的心脏自主神经系统效应  

Effect of Atropine on Cardiac Autonomic Nervous System

作　　者：谢正祥[1] 牛永红[1] 殷跃辉[2] 李章勇[1] 徐晓红[1] 

机构地区：[1]重庆医科大学生物医学工程研究室,重庆市400016 [2]重庆医科大学第二临床学院心内科,重庆市400010

出　　处：《中国药房》2002年第5期265-267,共3页China Pharmacy

基　　金：卫生部科学基金资助项目 (94-1-352);重庆市科学基金资助项目 (99-18-58)

摘　　要：目的 :研究阿托品的心脏自主神经系统效应。方法 :用我室研制的计算机化分析系统 ,测定自愿受试者在给予阿托品(0 04mg/kg,iv)前和后1小时心动周期信号的特征参数。结果 :阿托品使心动周期、心动周期的标准差、谱的总功率、谱的高频成分显著降低 ,心率和谱的超低频成分的相对值显著增加。结论 :(1)阿托品能使心动周期的标准差 (或心率的标准差 )显著降低 ,意味着心率的不整齐性的降低 ,这是使心动周期信号谱的高频成分的绝对值和相对值显著降低的根本原因 ,也是副交感神经的张力降低的根本原因 ;(2)阿托品能相对增加交感神经的张力 ,降低副交感神经的张力 ,降低自主神经系统的张力 (表现为心动周期信号谱的总功率显著降低 )OBJECTIVE:To study the effects of atropine on cardiac autonomic nervous system.METHODS:Using the computerized analysis system developed by our laboratory,the characteristic parameters of heart period signal(HPS)in volunteers were examined before and 1 hour after administrating atropine(0.04mg iv).RESULTS:Atropine could decrease the mean heart period,standard deviation of heart period,high frequency components and total power of HPS spectra,and increase heart rate,relative power of ultra-low frequency components significantly.CONCLUSION:(1)Atropine can decrease standard deviation of heart period or heart rate,which means decreasing irregularity of heart rate.It is the basic reasons why high frequency components of HPS spectra increases,and parasympathetic nervous activity decreases,(2)Atropine can decrease the tonus of parasympathetic nerves,increase the tonus of sympathetic nerves relatively,and decrease the tonus of autonomic nervous system that reveals the decrease of the total power of HPS significantly.

关 键 词：阿托品 心动周期信号 谱分析 自主神经系统 

分 类 号：R971.92[医药卫生—药品]