地尔硫对环孢素A肾毒性的防护及血药浓度的影响  

The Effects of Diltiazem on the Blood Concentration and Renal Toxicity of CsA

作　　者：唐细兰[1] 宋湘芝[1] 洪良庆[1] 黎程 

机构地区：[1]中山医科大学附属第三医院,广州市510630 [2]解放军第177医院,广州市510315

出　　处：《中国药房》2002年第5期286-286,共1页China Pharmacy

摘　　要：目的 :了解肾移植术后患者应用地尔硫对环孢素A (CsA)血药浓度的影响及肾保护作用。方法 :选用25例肾移植患者分为两组 ,治疗组加用地尔硫 ,采用荧光偏振免疫分析法测定CsA的全血谷浓度。结果 :治疗组CsA的用量明显低于对照组 ,地尔硫能降低尿酸、血清肌酐、尿素氮水平。结论 :地尔硫能减少CsA用量 ,防护CsA肾毒性 。OBJECTIVE:To study the effects of diltiazem on the blood concentration and the renal toxicity of cyclosporin A(CsA) in patients with renal transplantation.METHODS: 25 patients with renal transplantation were divided into two groups,the therapeutic group were treated with diltiazem plus CsA and control group CsA alone and the valley blood concentration of CsA was detected by FPIA assay.RESULTS:The dosage of CsA in therapeutic group was less than that in control group significantly,the levels of UA,Scr and BUN in patients were decreased by diltiazem.CONCLUSION:The diltiazem therapy can decrease the dosage and toxic effect of CsA,then save the patient's medical costs.

关 键 词：环孢素A 地尔硫ZHUO 肾移植 血药浓度 防护 

分 类 号：R979.5[医药卫生—药品]