健康人单剂量口服他扎司特胶囊的尿药动学  

Pharmacokinetics of tazanolast capsule in human urine after administration of a single oral dose

作　　者：陈彬[1] 张晓光[1] 哈万鸿 代宗顺[3] 

机构地区：[1]鞍山市中心医院,辽宁鞍山114001 [2]辽宁省药品监督管理局,辽宁沈阳110003 [3]同济医科大学临床药理研究室,湖北武汉430030

出　　处：《中国医院药学杂志》2002年第5期265-267,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :建立反相HPLC法定量分析尿液中的他扎司特体内活性代谢物 ,研究其尿药动力学特征。方法 :8名健康受试者口服单剂量 75mg他扎司特胶囊后 ,按时间段收集尿液 ,反相HPLC法测定尿中活性代谢物浓度 ,考察 16h内尿药排泄变化。尿药排泄数据处理采用亏量法。结果 :主要药动学参数 :消除半衰期 (t1/ 2 )为 (1.8± 0 .6 )h ,累积尿药排泄量 (Xu∞)为(2 8.8± 7.7)mg ,累积排泄率 (P % )为 (48.0± 10 .6 ) %。结论OBJECTIVE A reversed phase high performance liquid chromatography has been established for determinating concentration of the active metabolite of tazanolast and studying its pharmacokinetics in human urine.METHODS After a single oral dose (75 mg) of tazanolast capsules were given to 8 healthy male volunteers, the urine samples were withdrawn up to 16 h and the active metabolite of tazanolast concentration in urine was assayed by RP HPLC. The excretion data in urine were disposed by sigma minus method.RESULTS The pharmacokinetic parameters were as follows: t 1/2 was( 1.8 ± 0.6 )h, X u ∞ was ( 28.8 ± 7.7 ) mg, P % was( 48.0 ± 10.6 )%?CONCLUSIONS This method is simple, precise and useable for pharmacokinetic studies of tazanolast in human being.

关 键 词：他扎司特 活性代谢物 高效液相色谱法 药动学 抗变态反应药 

分 类 号：R976[医药卫生—药品] R969.1[医药卫生—药学]