HBV携带者细胞免疫和体液免疫功能的变化  

Study on Change of Humoral and Cellular Immune Level of HBV Carriers

作　　者：黄锦生[1] 张慧敏[1] 陈惠珍[1] 

机构地区：[1]深圳市卫生防疫站,518020

出　　处：《中国公共卫生》2002年第5期551-552,共2页Chinese Journal of Public Health

基　　金：广东省医学科学研究基金;深圳市卫生科技计划经费资助分支题目 (编号 2 0 2 751;2 0 0 0 2 7)

摘　　要：目的　探讨HBV携带者细胞免疫和体液免疫功能的变化。方法　以ELISA法筛检确诊为HBsAg阳性而肝功能正常的 5 0名HBV携带者为观察对象 ,用免疫球蛋白测定试剂盒测定人体血清中的IgG、IgA、IgM ,用酶免定量测定试剂盒测定人体血清的IgE ,应用APAAP法测定人体外周血中的T淋巴细胞亚群。 结果　HBV携带者IgG、IgA、IgM水平比对照组有所下降 ,两者差异具有显著性意义 (P <0 0 5 ) ,IgE水平两者差异无显著性。HBV携带者CD+ 3 、CD+ 8均明显高于对照组 (P <0 0 1) ,CD+ 4 /CD+ 8低于对照组 (P <0 0 5 )。结论　HBV携带者体液免疫水平低下 ,HBV感染可激活CD+ 3 、CD+ 8T淋巴细胞的活性 ,引起HBV携带者细胞免疫功能紊乱。Objective To study on the change of humoral and cellular immune of HBV carriers.Methods 50 HBV carriers were screened by ELISA,whose HBsAg were positive and the indexes of liver functions are normal;IgG,IgA,IgM,IgE in serum were detected by immune globins detection kits and the subgroups of T immune cell detected by APAAP method.Results The levels of IgG,IgA,IgM of HBV carrier were significant lower than those of the normal control group( P <0 05),and the difference of IgE level was not significant.The levels of CD + 3 and CD + 8 were all significant higher than those of the normal control group( P <0 01),however the CD + 4/CD + 8 was lower than that of the normal group( P <0 05).Conclusion The humoral immune of HBV carriers was lower.HBV virus can stimulate the proliferation of CD + 4 and CD + 8,and lead to the function of celluar immune disorder.

关 键 词：HBV携带者 免疫功能 乙型肝炎 体液免疫 细胞免疫 

分 类 号：R512.620.3[医药卫生—内科学]