巴楚县2001年新疆出血热疫情的血清学证实  

Serologic studies of Xinjiang hemorrhagic fever in Bachu county, 2001

作　　者：韩磊[1] 唐青[1] 赵秀芹[1] 西条政幸 陶晓霞[1] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所出血热二部,北京102206 [2]日本国立感染症研究中心

出　　处：《中华流行病学杂志》2002年第3期179-181,共3页Chinese Journal of Epidemiology

基　　金：国家自然科学基金资助项目 (3 9870 680 )

摘　　要：目的　以血清流行病学方法调查新疆出血热 (XHF)病人、易感人群和主要宿主动物中疾病的感染情况。方法　分别收集 2 0 0 1年 4～ 6月新疆巴楚县临床诊断为XHF的病人血清、易感人群血清和主要宿主动物的血清 ,用研制的诊断试剂以酶联免疫吸附试验 (ELISA)检测XHF特异性IgG和IgM抗体 ;用抗原捕获ELISA检测XHF病毒抗原。 结果　病人血清IgG抗体阳性率为39 .6 2 % (2 1/ 5 3) ,IgM抗体阳性率为2 0 .75 % (11/ 5 3) ,抗原捕获ELISA有 1份血清为XHF抗原阳性 ;易感人群血清IgG抗体阳性率为 2 1.0 5 % (4/ 19) ,IgM抗体检测和抗原捕获ELISA全部为阴性 ;羊血清IgG抗体阳性率为 70 % (5 6 / 80 )。 结论　血清流行病学研究证实该次疫情确系XHF ,流行地区人畜均有较高水平的隐性感染。Objective To investigate the situation of Xinjiang hemorrhagic fever (XHF) in patients who have been diagnosed as XHF by clinical methods and to predict the condition in people who were liable to infection and in the host animals. Methods Sera collected from XHF patients and some peasants under the risk of contracting the disease, followed by checking the specific antibody against XHF with IgG ELISA and IgM capture ELISA, and XHF viral antigen with antigen capture ELISA. In addition, 80 sheep/goats serums were collected from two places where there were more XHF cases and specific IgG antibody against XHF checked by ELISA method. Results Positive rate of IgG and IgM antibodies were 39.62 % (21/53) and 20.75 % (11/53) respectively in the serums of patients; one patient's serum showed XHFV antigen positive by antigen capture ELISA. IgG antibody positive rate for peasants' sera was 21.05 % (4/19), but IgM antibody detection showed negative for all sera. In sera from 80 sheep and goats, 70%(56/80) showed IgG positive. Conclusion Results showed that XHF broke out in Bachu county from April to June 2001 while recessive infection of the disease remained serious.

关 键 词：巴楚县 2001年 新疆出血热 血清流行病学 克里米亚-刚果出热热 XHF 

分 类 号：R181.8[医药卫生—流行病学]