60例煤工尘肺患者气道反应性的研究  

Study on the bronchial responsiveness on patients with coal worker's pneumoconiosis(CWP)

作　　者：郭长轩[1] 贾维[1] 

机构地区：[1]淮北矿业集团公司职业病防治院,安徽淮北235000

出　　处：《中国职业医学》2002年第2期35-36,共2页China Occupational Medicine

摘　　要：目的　观察煤工尘肺患者气道高反应性 ,探讨尘肺期别、接尘时间、并发结核与气道高反应性的关系。方法　随机选取煤工尘肺患者 60例 ,以同地区正常老年男性 60人为对照组 ,分别用组织胺进行支气管激发试验 ,观察试验前后临床表现、组织胺浓度 (PC2 0 )、FEV1的变化情况 ,以受试者FEV1基础值降低 2 0 % (或更低 )的PC2 0 <8g/L判定为气道高反应性。结果　煤工尘肺组气道高反应 42例 ,对照组气道高反应 14例 ,两者差异有显著性 (P <0 .0 1) ;临床表现两组差异有显著性 (P <0 .0 1) ;接尘工龄与气道高反应性呈显著相关性 (r =-0 76,P <0 0 5 ) ;而尘肺期别、并发结核对气道高反应性无影响 (均P >0 .0 5 )。结论　煤工尘肺患者气道高反应性阳性率显著高于非煤工尘肺健康者 ,接尘工龄是其危险因素。Objective To explore the relationship between the CWP and bronchial hyperresponsiveness(BHR)and to find out the risk factors affecting the CWP patients' BHR such as CWP stage,exposure duration and tuberculosis complication. Methods 60 CWP patiens were randomly selected,compared with the 60 old healthy men in the same region.Bronchial provocation test using histamine was performed. PC 20 and FEV 1 were monitored while patients' clinical characteristics were described. The BHR were defined as a histamine concentration PC 20 <8 g/L which caused a fall in FEV 1≤20% from baseline. Results Bronchial responsiveness of CWP group was significantly higher than that of control group ( P <0.01). There was significant difference in clinical characteristic between the two groups ( P <0.01).Meanwhile there was an obvious correlation between the exposure years and BHR ( r=-0.76,P <0.05);the CWP stage and tuberculosis complication had no influence on the BHR of CWP patients.Conclusion The CWP patients did suffer from BHR and the exposure years seemed to be a risk factor.

关 键 词：煤工尘肺 气道反应性 组织胺浓度 

分 类 号：R135.2[医药卫生—劳动卫生]