西安地区急性GBV.C/HGV感染者的分子流行病学及临床特征  

Molecular epidemiology and clinical characteristics of acute infection patients with GBV-C/HGV in Xi'an region

作　　者：李如琳[1] 徐德忠[1] 聂青和[2] 闫永平[1] 张景霞[1] 

机构地区：[1]中国人民解放军第四军医大学流行病教研室,陕西省西安市710033 [2]中国人民解放军第四军医大学唐都医院全军感染病诊疗中心,陕西省西安市710038

出　　处：《世界华人消化杂志》2002年第3期299-304,共6页World Chinese Journal of Digestology

摘　　要：目的:为了了解西安地区急性GBV-C/HGV感染者的分子流行病学及临床特征。 方法:连续收集急性病毒性肝炎病例458例,诊断符合上海会议标准。经EHSA检测的67例非甲-戊型肝炎患者经套式PCR方法检测HGVRNA,采用统一《急性病毒性肝炎调查表》,由专人负责进行临床和流行病学调查。所有数据用EPI软件处理。 结果:经ELISA检测的67例非甲-戊型肝炎患者经套式PCR方法检测有17例呈HGVRNA阳性,50为诊断不明患者。通过对17例HGVRNA阳性患者的流行病学分布所进行的分析表明HGV极易感染抵抗力较弱的儿童和老年人,26岁以下占88.23％,与同一人群同年龄乙肝、丙肝和丁肝患者相比,明显增多,经x^2检验有统计学意义(P<0.05)。而当HGV与HCV或HBV同时感染时,致病力增强,可以使各年龄段人群感染。同时我们可以看到HGVRNA阳性患者于冬春季有一明显的发病高峰,尤以冬季为明显。 结论:GBV-C/HGV并不是临床急性肝炎的主要致病因子。HGVRNA阳性患者在暴露因素、流行病学及临床特征等方面具有与其他各型肝炎相同或相似的特点。AIM: To investigate the molecular epidemiology and clinical characteristics of acute infection patients with GBV-C/ HGV in Xi'an region.METHODS: We studied 458 acute hepatitis patients in Xian whose sera were tested, in which 67 were diagnosed as non A-E hepatitis. The 67 patients were tested with nested RT-PCR. An 'acute virus hepatitis investigation form' was adopted in the investigation of epidemiology and clinical studies performed by the specialists. All the data were analyzed with EPI software.RESULTS: Among the 67 cases of non A-E hepatitis, HGV RNA were detected positive in 17 sera samples (25.4 %) and accounted for 3.71 % in all the acute hepatitis patients in the hospital. The analysis of the epidemiological distribution of HGV RNA positive patients revealed that the children and old men with a weak resistance to the disease were infected with HGV easily. The group below 26 years old took up 88.23 %. There was statistically significant difference ( P < 0.05) in age ( < 26 years) between the group with HGV and with HBV, HCV and HDV. And the people in various age would be infected by HGV when it was co-infected with HBV or HCV. In the meantime, we noticed that the patients with HGV RNA positive had a significant high incidence in spring and winter,especially in the latter season. CONCLUSION: HGVRNA is not an important etiology of the clinical acute hepatitis. The clinical and epidemiological characteristics and the exposure factors of acute hepatitis in the patients with GBV-C/ HGV infection alone are similar to the patients with other known hepatitis viruses.

关 键 词：西安地区 急性GBV-C/HGV感染 分子流行病学 临床特征 

分 类 号：R512.6[医药卫生—内科学]