腹腔内毒素刺激后的大鼠脑功能磁共振成像研究  

A functional magnetic resonance imaging study of the brains of LPS- challenged rats

作　　者：王曦[1] 卢广[2] 杨运黄[2] 李丽云[2] 刘买利[2] 王百忍[1] 鞠躬[1] 

机构地区：[1]第四军医大学神经科学研究所神经免疫调节研究室,陕西西安710032 [2]中国科学院武汉物理与数学研究所,湖北武汉430071

出　　处：《中国神经科学杂志》2002年第2期543-546,共4页

基　　金：国家自然科学基金资助项目 (3 983 0 13 0 ) ;波谱与原子分子物理国家重点实验室基金资助项目

摘　　要：大鼠腹腔内给予内毒素脂多糖 (LPS)后 ,应用无创性、可连续观察的功能磁共振成像 (fMRI)技术观察前脑部分脑区局部血氧水平的变化。结果显示 ,视前区、下丘脑室旁核、扣带回和海马 /脉络组织区的fMRI信号强度在腹腔注射LPS后不同时间点呈现不规则的上升状态 ,提示这些区域参与了对外周注射LPS的反应。本研究说明fMRI可用于在神经免疫调节领域的研究中对实验动物脑内活动的无创性、可连续性观察。In order to elucidate the brain areas related to peripheral immune challenge, the blood oxygen level dependent magnetic resonance imaging (MRI) changes in several brain areas of the rat were observed consecutively following intraperitoneal lipopolysaccharide (LPS) stimulation. After LPS stimulation, the functional MRI (fMRI) signals enhanced in preoptic region, paraventricular nucleus of hypothalamus, cingulate cortex, hippocampus as well as choroid tissue. The results indicate that above mentioned structures are involved in the response of the brain to peripheral LPS stimulation. The present study also indicates that fMRI technique is an alternative method to study the brain function related to neuroimmunomodulation under harmless and consecutive observation.

关 键 词：腹腔 内毒素刺激 大鼠 脑功能磁共振成像 神经免疫调节 

分 类 号：R445.2[医药卫生—影像医学与核医学]