针刺对消化性溃疡患者内源性多肽的影响  

The Influence of Acupuncture on Endogenous Polypeptide in Patients with Peptic Ulcer

作　　者：郑关毅[1] 郑师碧[1] 韦立新[1] 

机构地区：[1]福建医科大学附属协和医院,福州350001

出　　处：《上海针灸杂志》2002年第2期10-11,共2页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的　探讨针刺调整胃肠道功能的机制。方法　检测 2 6例胃溃疡 (GU )、2 2例十二指肠溃疡 (DU )患者针刺足三里、公孙、胃俞等穴前后血浆β-内啡肽 (β- EP)、神经降压素 (NT)及血清胃动素 (MO)的含量 ,并与健康组 (2 5例 )进行比较。结果　GU组与 DU组血浆 NT含量低于对照组 ,而 MO、β- EP较之为高 (P<0 .0 1) ;针刺后 GU组与 DU组血浆 NT含量较针前为高 (P<0 .0 5 ,P<0 .0 1) ,而 MO、β- EP则较针前为低 (P<0 .0 1,P<0 .0 5 ) ,针刺后 GU组与 DU组症状总积分均较针前有明显下降 (P<0 .0 1)。结论　 NT、β- EP、MO的分泌失调是消化性溃疡 (PU )形成与复发重要原因之一。针刺治疗 PU与改善其NT、β- EP、MO的分泌失调状态 。Purpose To investigate the mechanism of acupuncture regulating gastrointestinal functions. Method Plasma β endorphin(β EP) and neurotensis(NT), and serum motilin(MO) contents were measured before and after acupuncture of points Zusanli(ST 36), Gongsun(SP 4) and Weishu(BL 21) in 26 cases of gastric ulcer(GU) and 22 cases of duodenal ulcer(DU), which were compared with those in a health group(25 subjects). Results Plasma NT content was lower while MO and β EP were higher in GU and DU groups than in the control group. In GU and DU groups, plasma NT content was higher( P <0.05 and P <0.01) while MO and β EP were lower ( P <0.01 and P <0.05) after than before acupuncture. In both GU and DU group, the symptom score was significantly decreased after acupuncture as compared with before acupuncture( P < 0.01 ). Conclusion The disturbance of NT, β EP and MO secretion is one of the causes of PU generation and recurrence. Acupuncture treatment of PU is related to improving NT, β EP and MO secretion and regulating gastrointestinal movements and functions.

关 键 词：消化性溃疡 内源性多肽 针刺疗法 临床研究 

分 类 号：R259.731[医药卫生—中西医结合] R246.1[医药卫生—中医内科学]