苓桂术甘汤对犬急性心肌缺血的影响  

Effects of Lingguizhugan Decoction on acute myocardial ischemia in dogs

作　　者：齐鑫[1] 王敏伟[1] 刘兴君[1] 宋宗华[1] 毕开顺[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2002年第3期208-213,共6页Journal of Shenyang Pharmaceutical University

摘　　要：目的研究苓桂术甘汤对犬急性心肌缺血、心脏血流动力学及心肌耗氧量的影响。方法采用结扎麻醉犬冠状动脉左前降支中段的方式 ,造成实验性急性心肌缺血病理模型 ,观察药物对心肌缺血、血流动力学及心肌耗氧量各指标的变化 (冠脉流量CBF、心输出量CO、心率HR、左室内压LVP、左室舒张末期压LVEDP、左室内压最大变化速率dp/dtmax等 )。结果苓桂术甘汤 8g/kg显著减少由NBT染色的心肌梗死面积 ,增加CBF ,降低冠脉阻力CVR、LVP、LVEDP、dp/dtmax、HR、氧利用率、耗氧指数、心肌耗氧量 ,与空白对照组及药前值比较差异有显著意义 (P <0 0 5～ 0 0 1 )。同时对血清磷酸激酶 (CPK)、乳酸脱氢酶 (LDH)、谷草转氨酶 (GST)没有明显影响。结论苓桂术甘汤能增加心肌的供血供氧 ,改善心肌缺血状况。Objective To observe the effects of the Lingguizhugan Decoction on acute myocardial ischemia, hemodynamics and myocardial oxygen consumption in dogs. Methods AMI model in which the anterior coronary artery was ligated in anesthetized dogs was built, the myocardial infarction area dyed by NBT was measured, the coronary arterial blood flow (CAF), cardiac output (CO), left ventricular pressure (LVP), the maximal left ventricular pressure rate change (dp/dtmax), blood pressure (BP), heart rate (HR), LVEDP and myocardial oxygen consumption were recorded by the polygraph system before and after intraduodenal administration of LGZGD. Results the Lingguizhugan Decoction 8 g/kg could obviously increase the coronary arterial blood flow (CAF), decrease CVR, LVP, LVEDP, HR, BSP, dp/dtmax, myocardial oxygen consumption, the differences were significant ( P <0.05-0.001) as compared with the control group and the level before administering LGZGD. The myocardial infarction area was reduced in 8 g/kg LGZGD as compared with the control group ( P <0 05).There is not remarkable effect on CPK,LDH,GST. Conclusions LGZGD could evidently increase the myocardial blood supply and oxygen supply, thus result in the improvement of myocardial ischemia.

关 键 词：苓桂术甘汤 急性心肌缺血 心肌耗氧量 冠脉流量 作用机制 心脏血流动力学 动物实验 

分 类 号：R259.422[医药卫生—中西医结合] R289.5[医药卫生—中医内科学]