黄芩甙对发热大鼠下丘脑PGE_2和cAMP含量的影响  

EFFECTS OF BAICALIN ON CONTENTS OF PGE_2 AND cAMP IN HYPOTHALAMUS OF FEVER RATS

作　　者：赵红艳[1] 张璠[1] 范书铎[1] 孙丽华[1] 

机构地区：[1]中国医科大学生理教研室,辽宁沈阳110001

出　　处：《中国应用生理学杂志》2002年第2期139-141,共3页Chinese Journal of Applied Physiology

基　　金：军事医学科学院创新基金

摘　　要：目的和方法 :PGE2 和cAMP是重要的中枢发热介质。为了探讨PGE2 和cAMP是否参与了黄芩甙解热的机制 ,本实验用内毒素 (ET)复制大鼠发热模型 ,观察黄芩甙的解热作用及对大鼠下丘脑中PGE2 和cAMP含量的影响。结果 :黄芩甙有明显的解热作用 ,并且翻转ET对下丘脑中PGE2 和cAMP含量的影响。相关分析显示 ,下丘脑中PGE2 和cAMP含量的变化与体温变化之间存在明显正相关。结论 :黄芩甙可通过抑制下丘脑中PGE2 和cAMP含量升高而发挥其解热作用。Aim and Methods: Both PGE 2 and cAMP are important neural mediator of fever.In order to discuss if PGE 2 and cAMP are involved in the antipyretic mechanism of baicalin,fever models of rats were made by I.V injection of endotoxin(ET).The antipyretic action and effects of baicalin on contens of PGE 2 and cAMP in hypothalamus were observed. Results: Baicalin possessed obvious antipyretic effect on fever rats and reversed the effect of ET on contents of PGE 2 and cAMP in hypothalamus.Correlation analysis showed that contents of PGE 2 and cAMP in hypothalamus were positively correlated with the change of body temperature of rats. Conclusion: Baicalin may exert its antipyretic effect on fever rats by inhibiting increase of contents of PGE 2 and cAMP in hypothalamus.

关 键 词：黄芩甙 发热大鼠 下丘脑PGE2 CAMP含量 解热作用 

分 类 号：R971.1[医药卫生—药品]