高血压患者血清Ⅲ型前胶原N端肽的变化及血管紧张素转换酶抑制剂对其影响  

Effect of angiotensin-converting enzyme inhibitor on serum aminoterminal propeptide of type Ⅲ procollagen in hypertensive patients

作　　者：周传伟[1] 鲁翔[1] 程蕴琳[1] 穆庆霞[1] 张爱萍[1] 娄小萍[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,南京210029

出　　处：《临床心血管病杂志》2002年第4期155-157,共3页Journal of Clinical Cardiology

摘　　要：目的 :观察高血压患者血清Ⅲ型前胶原N端肽 (PⅢNP)的变化以及血管紧张素转换酶抑制剂 (A CEI)对其影响。方法 :高血压患者 31例 (高血压组 ) ,并根据二维超声检查 (2 DE)结果分为伴或不伴心肌肥厚两个亚组。平衡放射免疫法测定各组患者ACEI治疗前后血清PⅢNP以及 2 DE等指标 ,并与 15例健康对照者(对照组 )进行比较。结果 :高血压组血清PⅢNP明显升高 ,经过 6个月ACEI治疗后显著下降 ,左室舒张功能也有类似变化。左室舒张功能参数 (A/E)以及左室质量指数与PⅢNP间存在正相关。结论 :血清PⅢNP在高血压患者中显著升高 ,提示存在心肌胶原代谢水平上升 ;而左室舒张功能参数与血清PⅢNP水平间的相关性提示纤维化可能是高血压患者出现舒张功能下降的原因。ACEI可以显著降低高血压患者的PⅢNP水平 。Objective:To evaluate effect of angiotensin-converting enzyme inhibitor on serum amino-terminal propeptide of type Ⅲ procollagen (PⅢNP) in hypertensive patients. Method:The levesl of serum PⅢNP, left ventricle mass index and A/E were measured in 31 hypertensive patients and in 15 normal control. Result: The level of PⅢNP in hypertensive patients was increased and decreased after 6 month ACEI therapy. A/E in hypertension group was decreased by ACEI therapy. The level of serum PⅢNP was correlated directly with LVMI and A/E.Conclusion:Angiotensin-converting enzyme inhibitor may reduce the level of serum of PⅢNP and A/E.

关 键 词：高血压 Ⅲ型前胶原 血管紧张素转换酶抑制剂 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]