尼尔雌醇加孕激素治疗绝经后骨质疏松症的研究  

Study on treatment of postmenopausal osteoporosis with nylestriol and progesterone

作　　者：廖二元[1] 邓小戈[1] 周智广[1] 王平芳[1] 伍汉文[1] 超楚生[1] 唐炜立[1] 伍贤平[1] 黄干[1] 彭健[1] 

机构地区：[1]中南大学湘雅二医院代谢内分泌研究所,长沙410011

出　　处：《中华内分泌代谢杂志》2002年第2期95-98,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家"九五"攻关项目 (96 90 6 0 5 0 5 );卫生部临床学科重点建设项目 (0 8 960 0 2 16);湖南省社会发展科研计划(99SSY10 0 9 10 )

摘　　要：目的　观察小剂量雌孕激素复方制剂 (每片含尼尔雌醇 0 .5mg ,左炔诺酮 0 .15mg ,每周口服 1片 )防治绝经后骨质疏松症的一年临床疗效。方法　随机对照 (自身对照及组间对照 )分组 ,双盲比较观察绝经后骨质疏松患者 119例用药与 72例用安慰剂 1年对绝经后骨质疏松症的疗效。结果　小剂量雌、孕激素制剂可阻止骨质疏松的发展 (P <0 .0 5 ) ,同时用药者的肝、肾功能 ,乳腺红外线扫描 ,子宫内膜厚度和子宫大小B超 ,阴道脱落细胞学形态等均与对照组差异无显著性 ,亦无阴道流血发生。结论　小剂量雌孕激素替代疗法具有疗效确切、副作用少、服用方便等优点 。Objective To investigate the therapeutic effect of compound nylestriol tablet (CNT), containing 0.5 mg of nylestriol and 0.15 mg of levonorgestrel per tablet, on patients with postmenopausal osteoporosis for one year. Methods One year′s clinical observation was performed in 119 patients treated with CNT (1 tablet per week) and 72 patients with placebo by a randomized, double blinded, placebo controlled study. Results CNT treated patients had a significantly lower bone mass loss than that of controls (P<0.05). There were no differences of other biochemical parameters between CNT and placebo treated patients, including serum alkaline phosphatase, calcium, phosphate, uric acid, blood urea nitrogen and urine hydroxyproline, as well as the finding of infrared mammary gland scanning, endometrial thickness and size of uterus and morphology of vaginal exfoliated cells. No uterine bleeding or bone fracture was observed during one year′s treatment period. Conclusion Low dose of nylestriol and progesterone is effective, safe, and convenient in the treatment of postmenopausal osteoporosis.

关 键 词：雌激素 替代疗法 骨密度 尼尔雌醇 左炔诺孕酮 骨质疏松 

分 类 号：R58[医药卫生—内分泌]