雌性大鼠全身骨密度与腰椎骨密度的一致性研究  

Investigation of the consistency of bone mineral density between whole-body and lumbar spine in female rats

作　　者：张娜[1,2] 廖二元[1] 王闻博[1] 杨川[1] 邓小戈[1] 伍贤平[1] 伍汉文[1] 

机构地区：[1]中南大学湘雅二医院代谢内分泌研究所,长沙410011 [2]湖南医学高等专科学校临床系内科室

出　　处：《中华内分泌代谢杂志》2002年第2期120-122,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家九五攻关课题资助 (96 90 6 0 5 0 5 96 90 6 0 5 0 1)

摘　　要：目的　研究雌性大鼠同一个体的整体骨密度 (BMD)与在体和离体腰椎BMD的一致性 ,探讨大鼠在体腰椎与离体腰椎面积定位的异同对不同腰椎BMD的可能影响。方法　用扇形束双能X线吸收仪测量 4 4只雌性SD大鼠的全身BMD、骨矿含量 (BMC) ,同时测量大鼠在体第 3至 6腰椎 (L3～ 6)和各腰椎 (L3～ 6)的BMD、BMC和腰椎面积 ;并相应测量配对的离体腰椎 (L3～ 6)和各腰椎(L3～ 6)的BMD、BMC和腰椎面积。结果　雌性大鼠整体BMD与在体、离体L3～ 6和各腰椎 (L3～ 6)的BMD均为正相关 (r=0 .6 7～ 0 .85 ,P <0 .0 0 1)。配对在体与离体 (L3～ 6)的BMD和BMC均为正相关(r =0 .5 6～ 0 .85 ,P <0 .0 0 1)。除配对L5的腰椎面积未相关 (r =0 .2 1,P >0 .0 5 )外 ,其它配对L3 、L4、L6面积成正相关 (r=0 .35～ 0 .4 9,P <0 .0 5 )。比较L3～ 6的BMD ,得L6椎体的BMD大于L5、L4和L3 。结论　雌性大鼠的整体BMD与在体和离体腰椎的BMD具有较好的一致性。Objective To investigate the consistency of bone mineral density (BMD) between whole body and lumbar spine in vivo and in vitro of the same female rat and to explore the possible effect of different lumbar spine area in vivo and in vitro on BMD in female rats. Methods The whole body BMD, bone mineral content (BMC), and the BMD, BMC and bone area of lumbar spine 3～6 (L 3～6 ) in vivo and in vitro, and each lumbar spine (L 3～6 ) were measured by fan beam dual energy X ray absorptionmetry in 44 female rats. Results In female rats there were significantly positive correlations between whole body BMD, L 3～6 BMD in vivo and in vitro, and the BMD of each lumbar spine (r=0.67～0.85, P<0.001). Thereweresignificantlypositivecorrelationsbetween the BMD and BMC of L 3～6 in vivo and L 3～6 in vitro, (r=0.56～0.85, P<0.001). There was no correlation between the area of L 5 in vivo and the area of L 5 in vitro (r=0.21, P>0.05), there were correlations between the area of L 3, L 4, and L 6 in vivo, and the area of L 3, L 4, and L 6 in vitro (r=0.35～0.49, P<0.05). BMD of L 6 was larger than that of L 5, L 4, and L 3. Conclusion In female rats, there is significant consistency between the BMD of the whole body and the BMD of lumber spines in vivo and in vitro.

关 键 词：骨密度 光密度测定法 X线 骨质疏松 

分 类 号：R58[医药卫生—内分泌]