海人藻酸毁损大鼠纹状体边缘区后对海马长时程增强的影响  

Effects of kainic acid that damages the marginal division of rat striatum on hippocampal long-term potentiation

作　　者：王钧[1] 舒斯云[1] 包新民[1] 李胜修[1] 

机构地区：[1]第一军医大学神经科学研究所,广东广州510282

出　　处：《第一军医大学学报》2002年第2期132-133,136,共3页Journal of First Military Medical University

基　　金：国家自然科学基金(39770250);广东省科学基金(99050)

摘　　要：目的研究纹状体边缘区与脑内其他与学习记忆有关脑区间的关系。方法高频刺激穿通纤维-齿状回通路在海马诱发长时程增强(LTP),观察海人藻酸毁损纹状体边缘区后对海马LTP的影响。结果高频刺激穿通通路后,正常组和盐水对照组的群体峰电位幅度显著增加;毁损组动物在高频刺激后,群体峰电位增加幅度明显低于正常组和盐水对照组,毁损组的兴奋性突触后电位也明显低于正常组和盐水对照组。表明毁损边缘区后海马LTP明显降低。结论毁损纹状体边缘区后对海马LTP的形成有一定影响。Objective To investigatetherelationshipbetweenthemarginaldivision(MrD)of thestriatumandotherbrain regionsassociatedwithlearningandmemory.Methods Long-termpotentiation(LTP)was inducedby high-frequency stimulationof theperforantpath-dentategyrus,andchangesin hippocampalLTPafterdestructionof themarginaldivision withkainicacidwereobserved.Results High-frequencystimulationof theperforantpathproducedsignificantincreasesinthe peakamplitudesof thepopulationspike(PS)in normalratsandthosereceivingsalinetreatment.In ratswithdamagedMrD,theincreasein PS andtheexcitatorypostsynapticpotentialwerelessobviouscomparedwithnormalor saline-treatedrats,indicatingthattheLTPof thehippocampuswasattenuatedby damageof theMrD.Conclusion Damageof theMrDimpacts theLTPformationinthehippocampus.

关 键 词：长时程增强 海人藻酸 纹状体 边缘区 学习 记忆 

分 类 号：R338.26[医药卫生—人体生理学]