布洛芬分散片的研制  

Study on the preparation of dispersible ibuprofen tablets

作　　者：赵焰[1] 孙延清 翟光喜[1] 朱崇辉[3] 

机构地区：[1]山东大学药学院 [2]山东医药工业研究所 [3]青岛市第八人民医院

出　　处：《山东大学学报（医学版）》2002年第2期131-132,共2页Journal of Shandong University:Health Sciences

摘　　要：目的 :研制布洛芬分散片。方法 :以崩解时间为指标比较了不同崩解剂的作用 ,以正交试验设计确立最佳处方 ,并与普通片进行了体外溶出度的比较。结果 :崩解剂以交联聚乙烯吡咯烷酮效果最优 ,最佳处方崩解时间为 89.4s ,溶出速度远大于普通片。结论 :所研制的布洛芬分散片溶出迅速。Objective: To experiment on the preparation of dispersible ibuprofen tablets. Methods: With the dispersible time as the focus of attention, different disintegrants were compared and orthogonal design was adopted to determine the optimal formulation,and then dissolution rate of dispersible ibuprofen tablets was compared with that of the conventional tablets in the market. Results:Of the four tested disintegrants crospovidone had the best dispersing effect and the dispersible tablets of optimal formulation exhibited a disintegrating time of 89.4s with a much quicker dissolution speed than that of the conventional tablets on sale. Conclusion: The experimented dispersible ibuprofen tablets have a higher dissolution speed than those in the market.

关 键 词：布洛芬 分散片 正交设计 

分 类 号：R945[医药卫生—微生物与生化药学]