止嗽立效胶囊止咳、祛痰及平喘作用研究  

Antitussive, Expectorant and Antiasthmatic Actions of Zhisou Lixiao Capsule

作　　者：王卉[1] 尤春来[1] 穆培[1] 李云兴[1] 

机构地区：[1]辽宁中医学院药理教研室,沈阳110032

出　　处：《中药新药与临床药理》2002年第3期168-169,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的研究止嗽立效胶囊止咳、祛痰及平喘的药效作用。方法利用氨水引咳法,酚红法,毛细玻璃管引痰法及组胺喷雾致喘法来研究止嗽立效胶囊在止咳、祛痰、平喘方面的药理作用。结果止嗽立效胶囊3.2g·kg-1·d-1ig可明显延长小鼠咳嗽潜伏期,减少咳嗽次数;0.8～3.2g·kg-1·d-1ig能明显增加小鼠支气管酚红分泌量;0.5～2.0g·kg-1·d-1ig能增加大鼠支气管分泌物量;1.0～2.0g·kg-1·d-1ig能明显延长豚鼠组胺所致的哮喘潜伏期。结论止嗽立效胶囊具有良好的止咳、祛痰及平喘作用。Objective: To study the Antitussive, expectorant and antiasthmatic actions of Zhisou Lixiao capsule(ZLC). Methods: The incubation period and the frequency of cough in mice induced by ammonia water, the secretion of PSP from mouse bronchus and the incubation period of asthma in guinea-pigs induced by histamine were observed. Results: ZLC 0.8～3.2g·kg-1·d-1 ig could obviously prolong the incubative period of cough and decrease the frequency, ZLC 0.8～3.2g·kg-1·d-1 ig could increase the secretion of PSP in mice, 0.5～2.0 g·kg-1·d-1 increase the bronchial secretion in rats, and 1.0～2.0 g·kg-1·d-1 could prolong the incubation period of asthma in guinea-pigs. Conclusion: ZLC exerts a good Antitussive, expectorant and antiasthmatic effect.

关 键 词：止嗽立效胶囊 药理学 咳嗽 中药疗法 

分 类 号：R285.5[医药卫生—中药学] R256.11[医药卫生—中医学]