GC-MS分析石菖蒲挥发油透大鼠血脑屏障的成分研究  

GC-MS Determination of Naphtha from Acorus tatarinowii Schott. in Rat Brain

作　　者：方永奇[1] 魏刚[1] 柯雪红[1] 

机构地区：[1]广州中医药大学第一附属医院,广州510405

出　　处：《中药新药与临床药理》2002年第3期181-182,共2页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省中医药管理局科研基金课题(97189)。

摘　　要：目的探讨石菖蒲挥发油中有哪些成分能透过血脑屏障进入脑组织。方法采用GC-MS法对石菖蒲挥发油灌胃给药后进入大鼠脑组织中的挥发油成分进行分析。结果顺式甲基异丁香酚、榄香素、β-细辛醚、α-细辛醚4个成分能进入脑组织。结论石菖蒲挥发油开窍醒神的作用可能是多个成分综合作用的结果。Objective: To determine the component of naphtha from Acorus tatarinowii Schott.which can pass through the blood-brain barrier. Methods: Naphtha in rat brain was analyzed by GC-MS after gastric infusion of naphtha. Results: The methylisoeugenol,elemicin, β-asarone and α-asarone were detected in rat brain. Conclusion: The resuscitative effect of naphtha is resulted from the comprehensive action of multiple components.

关 键 词：石菖蒲挥发油 大鼠 血脑屏障 化学成分 GC-MS 

分 类 号：R284.1[医药卫生—中药学]