相思子毒素的分子特点及其在临床中的应用前景  

Molecular characteristics and clinical application prospect of abrin

作　　者：李丽琴[1] 郑晓军[1] 陈乐贵[1] 史瑞雪[1] 林福生[1] 

机构地区：[1]北京药物化学研究所,北京102205

出　　处：《中国新药杂志》2002年第5期360-363,共4页Chinese Journal of New Drugs

摘　　要：相思子毒素是从豆科植物 (AbrusPrecatoriusL .)种子中分离的一种细胞毒性蛋白。它由A ,B两条链组成 ,由一个二硫键相连 ,B链具有半乳糖凝集活性 ,可与细胞膜上受体结合 ,帮助A链进入细胞内 ,A链进入细胞催化 6 0S大亚基的 2 8SrRNA的第 4 32 4位脱去腺嘌呤而使 6 0S核糖体亚基失活 ,从而使细胞蛋白合成被抑制。本文综述了有关相思子毒素的分子结构特点。Abrin is one of the potent toxins isolated from the beans of plant Abrus precatorius L.The toxic protein consists of two disulfide bonded subunits,the A and B chain.The B chain is a galactose specific lectin that facilitates the binding of abrin to the cell membrane and the endocytosis of A chain.After entering the cells,the A chain catalytically inactivates 60S ribosomal subunits by removing adenine position 4324 of 28S r RNA,and thereby inhibits protein biosynthesis.The structural characteristics,toxicological mechanism and clinical application prospect of abrin were reviewed in this paper.

关 键 词：相思子毒素 结构特点 免疫毒素 临床应用 

分 类 号：R979.1[医药卫生—药品]