卡维地洛治疗轻中度高血压的临床疗效观察  

Effects of carvedilol on patients with mild to moderate essential hypertension

作　　者：何苗地 

机构地区：[1]诸暨市中医院心内科,浙江诸暨311800

出　　处：《临床心血管病杂志》2002年第5期213-215,共3页Journal of Clinical Cardiology

摘　　要：目的 :观察卡维地洛治疗轻、中度原发性高血压 (EH)的疗效及安全性。方法 :以倍他乐克作为对照 ,对 85例EH患者进行为期 8周的服药观察。经 2周安慰剂冲洗期后随机分组 ,治疗组给予卡维地洛 10mgbid ,服药 2周末血压下降未达有效标准者增加至 2 0mgbid ,疗程共 8周。对照组给予倍他乐克 2 5mgbid ,服药 2周末血压下降未达有效标准者增加至 5 0mgbid ,疗程共 8周。 结果 :与用药前相比 ,两组用药后 2～ 8周的血压均较用药前明显下降 (P <0 .0 5 )。卡维地洛降压总有效率 80 .1% ,显效率 6 1.4 % ;对照组总有效率 76 .3% ,显效率 5 3.7% ,两组疗效比较 ,差异无显著性意义 (P >0 .0 5 )。卡维地洛服药前、后患者肝肾功能、空腹血糖、血脂、血常规、尿常规、心电图均无明显改变 (P >0 .0 5 ) ,不良反应轻 ,心动过缓、头晕、乏力各 1例。结论 :卡维地洛治疗轻、中度EH有效且安全性良好。Objective:To evaluate the efficacy and safety of Cavedilol in treating essential hypertension. Method:Eight five cases with mild to moderate essential hypertension were randomly divided into 2 groups, of which 44 received Carvedioll (10 mg, bid) and 41 received Betaloc ( 25 mg, bid) for 2 weeks. The doses of Carvedilol and Betaloc were increased to 20 mg and 50 mg, bid, respectively after 2 weeks treatment according to the blood pressure. Efficacy was evaluated 8 weeks after treatment. Result:After treament, the blood pressure was significantly decreased in 2～8 weeks in both Cavedilol and Betaloc group (P< 0.05 ). The total response rate and the effective rate were 80.1 % and 61.4 % respectively in the Cavedilol group. Furthemore, the diastolic pressure and systolic pressure in Cavedilol group reduced by 10.8 mmHg and 19.5 mmHg respectively without the change of heart rate (P> 0.05 ). Both groups had no severe adverse reactions (P> 0.05 ).Conclusion:Carvedilol is effective and safe in treating mild to moderate essential hypertension.

关 键 词：高血压 卡维地洛 肾上腺素能Β受体阻滞剂 

分 类 号：R972[医药卫生—药品]