酪酸梭菌的抑菌作用研究  

Inhibitory effect of Clostridium butyricum(C B) on bacteria

作　　者：张树波[1] 崔云龙 吴顺娥[1] 刘端[1] 万阜昌 

机构地区：[1]中国预防医学科学院流行病学微生物学研究所,北京100050 [2]北京天施康医药科技发展有限公司,北京100037

出　　处：《中国新药杂志》2002年第4期322-324,共3页Chinese Journal of New Drugs

摘　　要：目的 :研究酪酸梭菌对肠出血性大肠杆菌、痢疾志贺菌、霍乱沙门菌、霍乱弧菌等肠道致病菌以及婴儿双歧杆菌的抑制作用。方法 :先将酪酸梭菌、痢疾杆菌等分别进行单独培养 ,测定不同培养时间内的pH值和活菌数 ,然后将酪酸梭菌分别和致病菌进行混合培养 ,再测量 pH值和活菌数 ,并与单独培养时的测定情况进行比较。结果 :酪酸梭菌对婴儿双歧杆菌无抑制作用 ,对肠出血性大肠杆菌、痢疾志贺菌、霍乱沙门菌、霍乱弧菌均有显著的抑制作用。结论Objective:To study the inhibitory effect of Clostridium butyricum(C B) on Enterohemorrhagic Escherichia.coli (EHEC), Shigella dysenteriae , Salmonella cholerae , Cholera vibrio which belong to pathogenic bacteria of intestinal tract as well as Bifidobacterium infatis .Methods:C B and other bacteria was singly cultured respeclively,and pH levels and viable bacteria amounts were determined at various time,then C B were mixedly cultured with other bacteria respectively,and pH levels and viable bacteria amounts were also determined,and the data obtained from the single and mixed cultwre were compared.Results:C B had no inhibitory effect on the Bifidobacterium infatis but had obvious inhibitory effect on the EHEC, Shigella dysenteriae , Salmonella cholerae and Cholera vibrio .Conclusion:C B is of obvious inhibitory effect on the pathyogenic becteriae of intestinal tract.

关 键 词：酪酸梭菌 单独培养 混合培养 抑菌作用 

分 类 号：R975[医药卫生—药品]