肿瘤血瘀证实质及活血化瘀治则的研究  

Study on the mechanism of tumor blood stasis syndrome and the principle of treatment for promoting blood circulation and removing blood stasis

作　　者：刘永惠[1] 杨晓峰[1] 周冬枝[1] 

机构地区：[1]西安交通大学第一医院,西安710061

出　　处：《河北中医》2002年第4期252-254,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的　阐述肿瘤血瘀证与纤维蛋白原 (Fng)的关系 ,进一步探讨肿瘤血瘀证的实质及活血化瘀治则的临床应用。方法　采用比浊法测定 77例原发性肺癌患者Fng含量 ,其中肺癌组 (未转移者 ) 5 0例 ,转移组 2 7例和健康人对照组 2 0例 ,并按中医辨证标准予以分型。结果　肺癌组、转移组较对照组Fng含量有显著性差异 (P <0 .0 5 ,P <0 .0 1 ) ,且转移组与肺癌组也有明显差异 (P <0 .0 5 ) ;中医辨证分型中具有血瘀证特征者 ,Fng含量增高尤其突出 ,与对照组比较有显著性差异 (P <0 .0 1 )。结论　高纤维蛋白原血症加剧肿瘤血瘀证 ,而肿瘤血瘀证的实质是血液凝固—纤溶—血小板功能紊乱。活血化瘀贯穿于中医治疗肿瘤的始终 ,在此基础上 ,根据辨证和病程辅以其它治则。Objective To elaborate the retationship between the tumor blood stasis syndrome and fibrinogen (Fng) and to investigate further the mechanism of tumor blood stasis syndrome and the principle of treatment for promoting blood circulation and removing blood stasis. Methods The Fng content in 22 healthy subjects and 77 patients with lung cancer was tested by turbidimetry, 50 cases of which were unmetastasis of lung cancer and 22 cases were metastasis. Results There were significant differences in Fng content between metastasis group and control group (P<0.05) and between unmetastasis group and cortrol group(P<0.01),as well as between unmetastasis group and metastasis group(P<0.05);Fng content in the patients with blood stasis syntromes was significantly increased (P<0.01).Conclusion Hyperfibrogenemia may deteriorate tumor blood stasis symptoms, whose mechanism is the disturbance of blood coagulation-fibroinolysis-platelet function. The promoting blood circulation and removing blood stasis is the important princeple of treatment,based on it, the other auxiliary therapeutic methods mey be used according to the traditional Chinese differentiation of syndrome and sign.

关 键 词：肿瘤 血瘀证 纤维蛋白原 活血化瘀 治则 中医药疗法 

分 类 号：R273[医药卫生—中西医结合] R730.52[医药卫生—中医肿瘤科]