血清肌钙蛋白I测定对暴发型流脑并发心肌损伤的研究  

Serum cardiac troponin I in diagnosis of myocardial injury complicated with meningococcal meningitis

作　　者：徐东杰[1] 徐晋丹[1] 卞智萍[1] 陈相健[1] 殷国庆[2] 张寄南[1] 

机构地区：[1]南京医科大学第一附属医院心内科,心血管病研究所,210029 [2]南京市第二医院

出　　处：《江苏医药》2002年第6期417-419,I002,共4页Jiangsu Medical Journal

基　　金：江苏省科委社会发展基金(BS980 39与BS970 2 8)

摘　　要：目的　探讨暴发型流行性脑脊髓膜炎 (流脑 ,FMM )患者并发的心肌损伤。方法　 1 6例生前有心功能不全病史的暴发型流脑患者 ,分别在入院时及出现临床心力衰竭或中枢神经系统症状时抽血测定血清肌钙蛋白I(cTnI)浓度 ,部分病例死亡后立即穿刺心室肌 ,制成超薄切片后电镜观察超微结构改变。结果　 1 6例患者临床症状明显时血清cTnI浓度均明显增高 (P <0 0 0 1 ) ,电镜示有心肌细胞变性坏死及肌丝破坏。结论　暴发型流脑常并发心肌损伤 。Objective To evaluate the cardiac injury in patients with fulminant meningococcal meningitis(FMM).Methods Serum cardiac troponin I was assayed by ELISA method in sixteen patients of fulminant meningococcal meningitis with acute heart failure when they were admitted to hospital and had signs of heart failure.Part of patients were punctured to myocardium as soon as they died.Microstructure of heart was studied with electrical microscope.Results Serum cardiac troponin I elevated in sixteen patients at the onset of heart failure compared with negative serum cardiac troponin I at the admission(5 19±0 43ng/ml vs 17 21±9 31ng/ml, P <0 001).Pictures of electrical microscope showed cardiomyocyte necrosis and myofilament destruction.Conclusion Patients with FMM may have cardiac injury.Serum cardiac troponin I was a highly sensitive and specific marker for determining cardiac injury in those patients,especially when complicated with acute heart failure.

关 键 词：暴发型流行性脑脊髓膜炎 血清 肌钙蛋白I 测定 并发症 心肌损伤 研究 

分 类 号：R512.3[医药卫生—内科学] R542.2[医药卫生—临床医学]