扩展青霉脂肪酶预防高血脂症的实验研究  

Study on the Effect of Lipase from Penisillium Expansum on Preventing Hyperlipemia

作　　者：王毅[1] 徐乐焱[2] 邱炳源[3] 郭英[3] 

机构地区：[1]吉林大学再生医学科学研究所,中国吉林长春130021 [2]北京协和医科大学放射科 [3]吉林大学公共卫生学院

出　　处：《实用预防医学》2002年第2期101-103,共3页Practical Preventive Medicine

摘　　要：目的　观察扩展青霉脂肪酶对动物血脂和血液粘度等指标的影响 ,为其在医药卫生领域的应用提供科学依据。　方法　测定脂肪酶实验组与正常对照组、高脂实验组在体重、肝重、血脂、血液流变等指标的差异。　结果　 1脂肪酶实验组大鼠的体重、肝脏重量、与正常对照组无显著性差异 ;2脂肪酶实验组血中甘油三酯 ( TG)、胆固醇 ( TC)和低密度脂蛋白 ( L DL- C)显著低于高脂对照组 ( P<0 .0 5 ) ,而其高密度脂蛋白 ( HDL- C)显著高于高脂对照组 ( P<0 .0 1) ;脂肪酶实验组的全血粘度 (高、低切 )、全血还原粘度 (低切 )、血沉 ( ESR)等指标与高脂对照组相比有明显改善。Objective To study the effect of lipase from penisillium expansum on serum lipid and blood viscosity of mice, To provide scientific basis for further usage of lipase from penisillium expansum in medical area. Methods The body weight,liver weight,serum lipid and hemorrheology data were measured. Result ①there was no significant difference on body and liver weight between the lipase preventive group and the normal control group.②thr serum TG,TC and LDL-C of lipase group decreased markedly(P<0 05) and the serum HDL-C increased significantly compared with high fat diet group(P<0.05). The BVL,BVH,BRVL and ESR of lipase group improved significantly compared with those of the high fat diet group. Conclusion This implied that lipase from Penisillium expansum could prevent the increase of serum lipids and improve hemorrheology.

关 键 词：扩展青霉脂肪酶 高血脂症 血液流变学 

分 类 号：R589.2[医药卫生—内分泌]