各期日本血吸虫病人治疗前后HBV感染血清标志物的比较分析  

Comparative Analysis on HBV Infection Serum Marker in Different Stages of Schistosomiasis Japonica Pre-and post-Chemotherapy.

作　　者：朱剑君[1] 汪军[1] 刘学青[1] 

机构地区：[1]湖南省血吸虫病防治研究所,中国湖南岳阳414000

出　　处：《实用预防医学》2002年第2期130-132,共3页Practical Preventive Medicine

摘　　要：目的　了解各期血吸虫病人治疗前后 HBV感染标志物的变化。　方法　对 80例急性期、78例慢性期及 60例晚期血吸虫病人吡喹酮杀虫治疗 ,用 EL ISA法测定治疗前后 HBV5项标志物含量。　结果　急性血吸虫病人治疗前后HBV阳性率分别为 62 .5 0 %和 2 8.75 % ,慢性血吸虫病人治疗前后 HBV阳性率分别为 2 8.2 1%和 3 0 .77% ,且各项阳性率与对照人群相似 ;晚期血吸虫病人治疗前后 HBV感染标志物阳性率分别为 5 0 .0 0 %和 5 3 .3 3 % ,两者无显著性差异 ,但其小三阳阳性率治疗前后分别为 3 3 .3 3 %和 3 1.67% ,在各组病例中最高。　结论　急性血吸虫病人治疗前 HBV阳性率明显高于治疗后 ,且 HBV感染标志物组合阳性率也是治疗前高于治疗后。慢性和晚期血吸虫病人 HBV感染率治疗前后变化不大 ,但晚期血吸虫病人 HBV感染标志物小三阳和大三阳的阳性率高于慢性和急性治疗后。Objective To understand the change of HBV infection serum marker in different stages of schistosomiasis Japonica pre and post-chemotherapy. Methods HBsAg, HBeAg, Anti-HBs, Anti-HBe and Anti-HBc were detected in 80 patients with acute S Japonica, 78 patients with chronic S japonica, 60 patients with advanced S japonica pre-and post-chemotherapy by ELISA. All patients were treated with praziquantel. Results The positive rate of HBV infection in patients with acute S japonica was 62.50%, 28.75% respectively before and after chemotherapy; The positive rate of HBV infection in patients with chronic S Japonica was 28.21% and 30.77% resptctively, and there was no difference contrast between pre-and post-chemotherapy. The positive rate of each HBV serum marker in the cases corresponded with the control group. There were no statistical significance between pre-and post-chemotherapy, that in advanced S Japonica was 50.00% and 53.33% respectively. But the positive rate of HBsAg and Anti-HBc in advanced S Japonica is the highest, which is 33.33%, 31.67% respectively before and after therapy. Conclusions The positive rate of HBV infection in acute S Japonica pre-chemotherapy was significantly higher than that in post-chemitherapy. The positive rate of HBV infection in chronic and advanced S Japonica has no difference between pre-and post-chemotherapy, but the positive rate of HBV infection serum marker(HBsAg? Anti-HBc? Anti-HBe/HBeAg) in advanced S Japonica was higher than in chronic or acute S Japonica post-chemotherapy.

关 键 词：日本血吸虫病 HBV感染 血清标志物 

分 类 号：R532.21[医药卫生—内科学]