P-选凝素与心肌缺血-再灌注损伤  

P-selectin and Myocardial Ischemia-Reperfusion Injury

作　　者：穆军升[1] 

机构地区：[1]上海第二医科大学附属仁济医院胸心外科,上海200001

出　　处：《中国胸心血管外科临床杂志》2002年第2期129-132,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：研究心肌缺血 -再灌注损伤中 P-选凝素 ( P- selectin)的重要作用。P- selectin是一种糖蛋白黏附因子 ,存在于内皮细胞和血小板 ,并介导血小板、内皮细胞和多形核白细胞 ( PMNs)等之间的相互作用 ,且与一氧化氮有着密切的关系 ,形成了许多复杂的炎症病理过程 ,在心肌缺血 -再灌注损伤中起到了关键的作用。特别是 P- selectin与晚期再灌注损伤、血小板及心肌损伤中治疗作用、最新的 P- selectin基因缺陷小鼠和糖尿病小鼠等的心肌缺血 -再灌注损伤中表现的深入研究 ,使其在缺血 -再灌注损伤中的重要性和复杂性显得更加突出。To understand the important role of P selectin in process of myocardial ischemia reperfusion injury, related literatures have been reviewed. The P selectin is a glycoprotein adhesion molecule that rapidly expressed on the surface of platelets and endothelium during inflammatory reaction. P selectin can mediate interactions among platelet, endothelium and polymorphonucleocytes. P selectin on platelets and endothelial cells plays an important role in myocardial ischemia reperfusion injury. At present, the main study is focused on late reperfusion injury in diabetic mouse and P selectin knockout mice. The importance and complexity of the role of P selectin in myocardial ischemia reperfusion injury has been more attractive.

关 键 词：P-选凝素 心肌缺血 再灌注损伤 血小板 内皮细胞 多形核白细胞 

分 类 号：R654.2[医药卫生—外科学]