盘内外胶原酶溶核术治疗不同类型腰椎间盘突出症的临床研究  

Intradiscal and Epidural Injection of Collagenase for Treatment of Various Lumbar Disc Herniations. A Clinical Study

作　　者：蒋煜青[1] 余庆阳[1] 马小敏[1] 陈绛志 邱丽红[1] 曹俊寿[1] 

机构地区：[1]福建省龙岩市第一医院,福建龙岩364000

出　　处：《中国中医骨伤科杂志》2002年第2期21-24,共4页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：福建省自然科学基金项目 ( 2 0 0 0 Z14 1)

摘　　要：目的 :评价盘内外胶原酶注射治疗突出型和脱出型腰椎间盘突出症的临床疗效。方法 :对 99例依据 CT和 /或 MRI检查 ,病理分型属突出型和脱出型的腰椎间盘突出症患者 ,全部采用盘内外胶原酶注射法治疗 ,盘内、外胶原酶用量各 6 0 0 U,并分别于术后 1 / 2～ 1个月内 (近期 )和 3个月之后 (中远期 )随访。结果 :突出型和脱出型腰突症组近期优良率分别为 71 .9% / 5 0 .0 % ;中远期优良率分别为 80 .8% / 71 .8% ;组间无显著性差异 ( P>0 .0 5 )。结论 :盘内外胶原酶注射法是治疗腰椎间盘突出症的一种有效手段 ,特别是对突出物较大的脱出型患者亦可取得满意疗效 。Objective: To study the effect and correlation factor of intradiscal and epidural injection of collagenase for treatment of protrusion and prolapsed lumbar disc herniations.Methods: Ninety-nine patients with proven lumbar disc displacement by Computer tomography and/or MRI were treated by intradiscal and epidural injection of collagenase with 600u/disc. Postoperative patients followed up within half to one month(short-term) and after three months (metaphase and long-term).Results:There shows 71.9%/50.0% of success rate and 80.8%/71.8% of succees rate at short-term and metaphase and long-term in the group of protrusion and prolapsed lumbar disc herniations respectively.There is insignificant difference between two groups(P<0.05). Also,The effect of metaphase and long-term has no relation with sex, ages and sick time(P<0.05).Conclusion:Intradiscal and epidural injection of collagenase is a valid method for treatment of lumbar disc herniations, particular has satisfying effect for patients of prolapsed lumbar disc herniations with large protrusion. Thereby, clinical accommodation coverage is augmented.

关 键 词：腰椎 病理 椎间盘移位 药物治疗 胶原酶椎间盘化学溶解术 

分 类 号：R681.5[医药卫生—骨科学]