吸入氧浓度对全麻病人血浆SOD和MDA的影响  

Effects of fraction of inhaled oxygen on serum SOD and MDA in patients under general anesthesia

作　　者：赵宏[1] 常靖[2] 龙路路 

机构地区：[1]中国医科大学第三临床学院麻醉科,沈阳市110022 [2]沈阳医学院附属中心医院麻醉科 [3]沈阳铁路局医院内科

出　　处：《临床麻醉学杂志》2002年第5期250-251,共2页Journal of Clinical Anesthesiology

基　　金：辽宁省自然科学基金资助课题 (No :9810 5 0 0 30 2 )

摘　　要：目的　观察吸氧对全麻病人抗氧化损伤能力的影响。方法　选全麻病人 32例 ,分为A、B、C和D四组 ,麻醉中分别吸入 30 %、5 0 %、75 %和 10 0 %浓度氧。于麻醉前 ,麻醉后 2 0、6 0分钟 ,拔管前和拔管后 10分钟采血测定血浆超氧化物歧化酶 (SOD)活力和丙二醛 (MDA)浓度。结果　麻醉后各组MDA浓度逐渐增加 ,SOD活力逐渐降低。与麻醉前相比 ,从麻醉后 6 0分钟起逐渐出现显著差异。与A组相比 ,B、C组拔管前和B、C、D组拔管后 10分钟时SOD显著降低 ;C组 6 0分钟时 ,C、D组拔管前及B、C、D组拔管后 10分钟时MDA显著升高。结论　吸入高浓度氧可使全麻病人血浆MDA浓度升高 ,SOD活力降低 。Objective To observe the effects of fraction of inhaled oxygen (F IO 2)on serum superoxide dismutase (SOD)and malondialdehyde (MDA) in patients under general anesthesia.Methods Thirty-two patients (ASAⅠ-Ⅱ grade) scheduled for epigastric surgery under general anesthesia were randomly divided into four groups.The patients in group A inhalated 30% oxygen,and those in group B,C and D received 50%,75% and 100% oxygen respectively.The arteral blood samples for SOD and MDA measurments were taken before anesthesia,at 20 and 60 min during anesthsia,before extubation and at 10min after extubation.Results The SOD values decreased and the MDA values increased significantly from 60min during anesthesia to 10min after extubation gradually compared with those before anesthesia in all groups.The SOD values before extubation in group B and C and 10min after extubation in group B,C and D were lower and the MDA values at 60min during anesthesia in group C,before extubation in group C and D and 10min after extubation in group B,C and D were higher significantly than those in group A.Conclusion High F IO 2 can decrease serum SOD activity and increase serum MDA concentration in patients under general anesthesia,and appears to be a disadvantageous factor to protect patients from hypoxic injury.

关 键 词：吸氧 超氧化物歧化酶 丙二醛 全身麻醉 

分 类 号：R614[医药卫生—麻醉学]