HBV非e抗原标志物阳性产妇HBV DNA母乳传播的PCR定量研究  

The study on the maternal-milk transmission of HBV in non-HbeAg-positive mothers by fluorogenic quantitative PCR.

作　　者：林玲[1] 高锦声[2] 章杏珍[1] 张兰英[1] 

机构地区：[1]苏州市妇幼保健院,215004 [2]苏州医学院医学遗传研究中心

出　　处：《中国优生与遗传杂志》2001年第4期11-12,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 :探讨乙肝病毒 (HBV)非e抗原标志物阳性产妇的血清与初乳中HBVDNA含量的关系。方法 :用荧光定量PCR检测 2 6例HBV非e抗原标志物阳性产妇的血清及初乳中HBVDNA含量。结果 :该类产妇初乳中HBVDNA含量明显高于血清中含量 (拷贝值P <0 .0 5 ,荧光值P <0 .0 1)。结论 :在HBV非e抗原标志物阳性产妇HBV不仅可以通过母乳传播 。Objective:To elucidate the relationship of HBV DNA loads between the serum and the maternal-milk of non-HbeAg-positive mothers.Methods:The HBV DNA loads of the serum and maternal milk of 26 non-HbeAg-positive mothers were determined respectively by fluorogenic quantitative PCR.Results:In these mothers,the maternal-milk HBV DNA level is higher than the serum HBV DNA level obviously.Conclusion:In these non-HbeAg-positive mothers,the maternal-milk transmission is one of the most important transmission ways of HBV.

关 键 词：HBV 非e抗原标志物 阳性 产妇 HBV-DNA 母乳传播 PCR 定量研究 

分 类 号：R715.3[医药卫生—妇产科学]