自由基对兔关节软骨细胞超微结构的影响  

THE EFFECT OF FREE RADICAL ON THE ULTRASTRCTURE OF RABBIT ARTICULAR CHONDROCYTES

作　　者：康勇 魏西秦[1] 周兰华[2] 张健[1] 

机构地区：[1]西安医科大学病理解剖学教研室 [2]西安医科大学生物化学教研室

出　　处：《西安医科大学学报》1991年第2期120-122,共3页Journal of Xi'an Medical University(Chinese)

基　　金：国家自然科学基金

摘　　要：本研究采用体外培养兔关节软骨细胞的方法,建立黄嘌呤-黄嘌呤氧化酶系产生的内源性自由基对软骨细胞影响的实验模型。用倒置显微镜动态观察,扫描及透射电镜超微结构观察等研究方法,初步探讨了内源性自由基对兔关节软骨细胞的影响。结果表明:黄嘌呤-黄嘌呤氧化酶系产生的内源性自由基对软骨细胞具有损伤作用。提示软骨老化、变性、一些变性性关节疾病,如大骨节病、关节炎的发生可能与自由基有关。Using the method of rabbit articular chondrocytesm monolayer culture in vitro, we have studied theultrastructural effed of free redicals generated by the ac-tion of xanthine oxidase on xanthine on thechondrocytes, The chondrocytes were observed undermicroscope and elcetron microscope.Our results showed that free radicals generated bythe action of xanthine oxidase on xanthine might damagethe chondrocytes. This suggested that free radicals mightbe related to the pathogenesis of cartilage aging,degener-ation, degenerative joint disease and arthritis.

关 键 词：软骨细胞 超微结构 自由基 关节 

分 类 号：R322.71[医药卫生—人体解剖和组织胚胎学]