氯卡胺对NE,KCl_2,CaCl诱发兔主动脉环收缩的影响  

Effects of Lorcanide on Contractions induced by Norepinephrine,Potassium Chloride,and Calcium Chloride in Isolated Rabbit Aortic Rings

作　　者：刘勇[1] 李慧玲[1] 刘惟莞[1] 李章文[1] 

机构地区：[1]湖北医学院药理学教研室

出　　处：《湖北医学院学报》1989年第2期125-128,共4页

摘　　要：氯卡胺系一抗心律失常药。本文用兔主动脉环研究了该药对NE,KCl,和CaCl_2诱发收缩的影响。结果表明氯卡胺显著降低NE 0.1μmol/L和KCl60mmol/L诱发的收缩,且非竞争性抑制NE浓度-效应曲线,pD′_2为3.6;竞争性抑制CaCl_2浓度-效应曲线,PA_2为4.6,从而提示氯卡胺抗复灌性心律失常作用可能与阻断α受体和电位依赖Ca^(2+)通道有关。Lorcanide is an antiarrhythmic drug.Rabbit aortic rings were used to investigate effects of lorcanide on contractions induced by norepinephrine, patassium chloride and calcium chloride.The results demonstrated that lorcanide markedly decreased the contractions induced by norepinephrine 0.1 μmol/L and potassium chloride 60 mmol/L.Also,lorcanide inhibited the concentration-response curve of norepinephrine in a non-competitive way with PD′_2 3.6 and the concentration response curve of calcium choride in a nearly competitive way with PA_2 4.6.Therefore,it suggested that the effect of lorcanide on arrhythmia induced by ligation and reperfusion might be related to its blockade of alpha receptor and dependent potential calcium channel.

关 键 词：氯卡胺 主动脉 罂粟碱 氯化钙 

分 类 号：R972.2[医药卫生—药品]