Ce^(3+)对细胞内游离Ca^(2+)的影响  

Effect of Ce^(3+) on Free Cytoplasmic Calcium of Cells

作　　者：申治国[1] 庄志雄[1] 黄海雄[1] 雷衡毅[2] 杨燕生[2] 

机构地区：[1]深圳市卫生防疫站,广东深圳518020 [2]中山大学化学与化学工程学院,广东广州510275

出　　处：《中国稀土学报》2002年第2期186-189,共4页Journal of the Chinese Society of Rare Earths

基　　金：国家自然科学基金 ( 2 96710 34 );广东省自然科学基金 ( 980 32 9)资助项目

摘　　要：研究了Ce3+ 对肝细胞和V79细胞中游离Ca2 + 的影响。低浓度的Ce3+ 能使肝细胞内游离Ca2 + 浓度增高 ,高浓度的Ce3+ 能使肝细胞内游离Ca2 + 浓度显著升高。Ce3+ 可促进细胞外Ca2 + 的内流 ,高浓度的Ce3+s: The effect of Ce 3+ on free cytoplasmic calcium of hepatocytes and V79 cells was studied with microfluorometry. The free cytoplasmic calcium in cells exposed to Ce 3+ increases in low dose and increases significantly in high dose. The free cytoplasmic calcium in hepatocytes exposed to Ce 3+ increases quickly at first and then decreases slowly. These results suggest that Ce 3+ might stimulate calcium inflow and enhance the free cytoplasmic calcium of cells. The result also suggestes that cerium might be toxic to hepatocytes in high dose.

关 键 词：稀土 铈 游离钙 肝细胞 显微荧光术 

分 类 号：R995[医药卫生—毒理学] O614.33[医药卫生—药学]